Pentraxin 3 as a novel diagnostic marker in neonatal sepsis
| Autor: | Sameh S. Fahmey, N Mostafa |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Gastroenterology Proinflammatory cytokine Sepsis 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests 030225 pediatrics Internal medicine medicine Humans Prospective Studies Pentraxin-3 030219 obstetrics & reproductive medicine Neonatal sepsis business.industry Infant Newborn Diagnostic marker PTX3 medicine.disease Serum Amyloid P-Component C-Reactive Protein ROC Curve Case-Control Studies Pediatrics Perinatology and Child Health Intensive Care Neonatal Biomarker (medicine) Female Inflammation Mediators Neonatal Sepsis business Biomarkers Signal Transduction |
| Zdroj: | Journal of Neonatal-Perinatal Medicine. 12:437-442 |
| ISSN: | 1878-4429 1934-5798 |
| Popis: | BACKGROUND Neonatal sepsis is an important cause of morbidity and mortality especially in developing countries. As clinical manifestations of neonatal sepsis are nonspecific, early diagnosis and treatment remain a challenge. Pentraxin 3 (PTX3) is an acute-phase protein secreted by various cells in response to the proinflammatory signals. Our aim was to investigate the diagnostic value of PTX3 in neonatal sepsis. METHODS We studied 90 neonates; 60 with culture-proven sepsis and 30 healthy neonates as a control group. Serum levels of PTX 3 were measured by ELISA. RESULTS Neonates with sepsis had significantly higher levels of PTX 3 as compared to controls (p |
| Databáze: | OpenAIRE |
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