Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment: A birth cohort study

Autor: Richard Saffery, Eva J. Sugeng, Nicole Wardrop, Jochen F. Mueller, Peter J. Anderson, Anne-Louise Ponsonby, David Burgner, Kristie Thompson, Peter D. Sly, Peter Vuillermin, Martin O'Hely, Angela Pezic, Toby Mansell, Fiona Collier, Soumini Vijayasarathy, Vicki Anderson, Sarath Ranganathan, Terence Dwyer, Christos Symeonides
Přispěvatelé: E&H: Environmental Health and Toxicology, AIMMS
Rok vydání: 2019
Předmět:
Candidate gene
Autism Spectrum Disorder
Twins
Physiology
Child Behavior
Toxicology
Nervous System
chemistry.chemical_compound
0302 clinical medicine
Child Development
Cognition
Phthalates
Pregnancy
Risk Factors
Autism spectrum disorder
0303 health sciences
education.field_of_study
General Neuroscience
Phthalate
Age Factors
Gestational age
Gene Expression Regulation
Developmental
Genetic score
Maternal Exposure
Child
Preschool
Prenatal Exposure Delayed Effects
Environmental Pollutants
Female
Population
Phthalic Acids
Gestational Age
Polymorphism
Single Nucleotide
Risk Assessment
03 medical and health sciences
SDG 3 - Good Health and Well-being
medicine
Humans
education
030304 developmental biology
business.industry
medicine.disease
Child development
Oxidative Stress
chemistry
Oxidative stress
Autism
Gene-Environment Interaction
business
030217 neurology & neurosurgery
Zdroj: the BIS Investigator Group 2020, ' Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment : A birth cohort study ', Neurotoxicology, vol. 80, pp. 20-28 . https://doi.org/10.1016/j.neuro.2020.05.006
Neurotoxicology, 80, 20-28. Elsevier
ISSN: 1872-9711
0161-813X
DOI: 10.1016/j.neuro.2020.05.006
Popis: Prenatal phthalate chemicals may have adverse effects on brain development by various mechanisms including oxidant damage. However, birth cohort findings have been conflicting. This study aimed to (i) investigate the interplay between maternal prenatal phthalate levels, infant genetic vulnerability to oxidative stress, and child neurodevelopment and (ii) examine combined putative oxidant exposures. In a population-based birth cohort of 1064 women with prenatal recruitment in Victoria, Australia, maternal urine was collected at 36 weeks of pregnancy and phthalate metabolite concentrations measured. An unweighted genetic score for oxidative stress was made using a candidate gene approach. Cognition was assessed using the BAYLEY-III at two years (n = 678). Parents completed questionnaires for doctor diagnosed autism spectrum disorder (ASD) (1.4 %), ASD traits (4.9 %) and child inattention/hyperactivity (n = 791). Analyses included multiple linear and logistic regression. Higher prenatal phthalate levels and a higher oxidative stress genetic score were each associated with subsequent ASD. Several oxidative stress-related SNPs modified the association between prenatal phthalates and ASD and other outcomes. Consistent patterns were evident across gene score-phthalate combinations for cognition, ASD, ASD traits and inattention/hyperactivity. Other putative oxidant factors such as prenatal smoking further increased risk. Prenatal phthalate levels and infant oxidative stress-related genetic vulnerability are associated with adverse neurodevelopment. Combined exposures are important. Current recommendations and regulation on maternal phthalate exposure during pregnancy require re-evaluation.
Databáze: OpenAIRE
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