Salvianolic acid B alleviates neurological injury by upregulating stanniocalcin 1 expression
| Autor: | Shao-Jie, Bi, Xin-Ying, Dong, Ze-Ying, Wang, Shan-Ji, Fu, Chang-Ling, Li, Zhao-Yang, Wang, Fei, Xie, Xue-Ying, Chen, Hao, Xu, Xiao-Jun, Cai, Ming-Xiang, Zhang |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Annals of Translational Medicine. 10:739-739 |
| ISSN: | 2305-5847 2305-5839 |
| Popis: | Salvianolic acid B (Sal B) is a representative component of phenolic acids derived from the dried root and rhizome ofIn the present study, ischemic stroke models were induced in rats by middle cerebral artery occlusion (MCAO), and Sal B (10 or 20 mg/kg/d) was intraperitoneally injected according to a previous study. Neurological deficits were evaluated by the modified Longa five-point scale, modified Bederson scores and cerebral infarction sizes by triphenyltetrazolium chloride (TTC) staining. Apoptotic cells were tested by cleaved-caspase3 immunofluorescence staining and an in situ cell death (TUNEL) detection kit. Human umbilical vein endothelial cells (HUVECs) exposed to hypoxia were used to investigate the effects of Sal B on angiogenesis and tube formationSal B ameliorated the neurological deficits, decreased the cerebral infarction volumes in rats with ischemic stroke, significantly increased the expression of vascular endothelial growth factor receptor 2 (VEGFR2) and VEGFA and promoted angiogenesis bothThis study showed that Sal B promoted angiogenesis and alleviated neurological apoptosis in rats with ischemic stroke by promoting STC1. |
| Databáze: | OpenAIRE |
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