Spatiotemporal Organization of the Proliferative System in Small Intestinal Crypt Epithelium of Intact Mice
| Autor: | S. S. Filippovich, Yu. A. Romanov, I. N. Malysheva, N. A. Zharkova, A. I. Antokhin, A. Yu. Kozlova |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Microvilli Crypt Epithelium Cell growth Photoperiod Crypt Epithelial Cells Cell subpopulations General Medicine Biology digestive system General Biochemistry Genetics and Molecular Biology Circadian Rhythm Cell biology Mice Basal (phylogenetics) Intestine Small Animals Outbred Strains Mitotic Index Animals Circadian rhythm Intestinal Mucosa Cell Division |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 136:599-603 |
| ISSN: | 0007-4888 |
| Popis: | We studied spatiotemporal organization of the proliferative system in small intestinal crypt epithelium of normal mice. Close relationships were found between circadian rhythms of cell proliferation and their position in the crypt. These peculiarities reflected spatiotemporal organization of the crypt epithelium. The hierarchic structure of spatiotemporal organization suggests the existence of several interrelated levels (individual cells, cell subpopulations, and cells with basal and maximum levels of proliferation within subpopulation). Each level has its proper temporal and spatial characteristics. Their interaction determines spatiotemporal organization of the proliferative system in the small intestinal crypt epithelium. |
| Databáze: | OpenAIRE |
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