Impairment of glucose metabolism in hearts from rats treated with endotoxin
| Autor: | Yvan Fischer, Jean-Philippe Tessier, Eberhard Jüngling, Andreas Lückhoff, Bernhard Thurner |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Lipopolysaccharides
Male Salmonella typhimurium medicine.medical_specialty Physiology medicine.medical_treatment Biology Rats Sprague-Dawley Thromboxane A2 chemistry.chemical_compound Insulin resistance Physiology (medical) Internal medicine medicine Ventricular Pressure Animals Glycolysis Glycogen synthase Glycogen Insulin Myocardium medicine.disease Myocardial Contraction Rats Perfusion Myocarditis Endocrinology Glucose chemistry Glycogenesis Salmonella Infections biology.protein Cardiology and Cardiovascular Medicine Biomarkers Phosphofructokinase |
| Zdroj: | Cardiovascular research. 60(1) |
| ISSN: | 0008-6363 |
| Popis: | Objective: In patients and animals with sepsis or critical illness, the mechanical function of the heart is often impaired. Although these conditions are accompanied by dramatic metabolic and hormonal changes, little is known about alterations of cardiac metabolism. In this study, we assessed the impact of an endotoxin-induced inflammation on cardiac glucose utilization. Methods: Bacterial endotoxin (1 mg/kg lipopolysaccharide from Salmonella typhimurium , LPS) was injected intravenously to rats. Six hours after LPS application, hearts were isolated and perfused in the Langendorff mode. Results: Left ventricular pressure was reduced by 50% in hearts from LPS-treated rats, compared to those from saline-injected control animals. With glucose as the sole fuel, there was no difference in glycolysis between the groups. However, on addition of β-hydroxybutyrate (an alternative fuel which inhibits phosphofructokinase via an increased citrate level), the glycolytic rate in the LPS group was 44 and 48% lower (in basal, and insulin-stimulated conditions, respectively; P |
| Databáze: | OpenAIRE |
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