Biosimilars as a Future, Promising Solution for Financial Toxicity: A Review with Emphasis on Bevacizumab
| Autor: | Janet Chan Gomez, Tabinda Saleem, Hafiz Qurashi, Tejaswi Kanderi, Munira Jamali |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Bevacizumab bevacizumab 030204 cardiovascular system & hematology Food and drug administration 03 medical and health sciences 0302 clinical medicine Trastuzumab Internal Medicine medicine biosimilars Intensive care medicine commercialization health care economics and organizations Cetuximab business.industry General Engineering oncologic application Biosimilar Critical appraisal Oncology global oncology costs Rituximab Public Health business 030217 neurology & neurosurgery Pegfilgrastim cost effective therapy medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.9300 |
| Popis: | A biosimilar is a biochemical product like another already approved biologic agent, known as the reference agent. To be endorsed by the Food and Drug Administration (FDA), biosimilars must demonstrate that they are as safe and effective as their reference item, with no clinical distinction. Humanized monoclonal antibodies (mAb) are revolutionizing the treatment of gastrointestinal and gynecologic malignancies. Bevacizumab, trastuzumab, cetuximab, rituximab, and pegfilgrastim are the most widely used mAb products with oncologic indications. Due to the complexities of the regulatory system, it may take time for anti-cancer biosimilars to play a significant game-changing role. Over the last decade, the use of generics has saved billions of dollars every year, and it is expected that biosimilars will soon prove to be a cost-effective alternative and can play an important role in driving down healthcare costs globally. In this review, we provide a critical appraisal of biosimilars with an emphasis on bevacizumab-awwb (Avastin) and its clinico-pharmacologic characteristics, safety, efficacy, interchangeability, regulatory and oncologic perspectives, and overall clinical perception. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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