Volume-selective Water-suppressed Proton Spectra of Human Brain and Musclein vivo
| Autor: | P. N. Venkatasubramanian, M. Bárány |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Magnetic Resonance Spectroscopy
Muscles Metabolite Brain Pulse sequence Human brain Biology Creatine Phosphocreatine chemistry.chemical_compound medicine.anatomical_structure Nuclear magnetic resonance chemistry medicine Humans Molecular Medicine Choline Radiology Nuclear Medicine and imaging Inositol Carnitine Spectroscopy medicine.drug |
| Zdroj: | NMR in Biomedicine. 2:7-11 |
| ISSN: | 1099-1492 0952-3480 |
| DOI: | 10.1002/nbm.1940020103 |
| Popis: | Volume-selective water-suppressed proton spectra were recorded from live human brain and muscle at 1.5T by combining a stimulated echo acquisition mode pulse sequence for localization and two saturation pulses for water suppression (Frahm et al., SMRM Abstracts, 1987). Metabolite signals were observed in voxels of size 4-64 cm3. Signals from -CH3 and beta-CH2 of N-acetylaspartate, =N-CH3 and =N-CH2 of phosphocreatine/creatine, -N(CH3)3 of choline and inositol protons were visible in the brain spectra from normal subjects. Differences in metabolite levels were observed between gray and white matters of brain from their water-suppressed spectra. Peaks from =N-CH3 of phosphocreatine/creatine and -N(CH3)3 of choline and carnitine were present in normal muscle spectra along with several resonances from fatty acyl chains. |
| Databáze: | OpenAIRE |
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