Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling
| Autor: | Alan H. Cherney, Julie L. Hofstra, Sarah E. Reisman, Ciara M. Ordner |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Allylic rearrangement
Stereoisomerism 010402 general chemistry 01 natural sciences Biochemistry Catalysis Article Stereocenter chemistry.chemical_compound Colloid and Surface Chemistry Nickel Silanes Molecular Structure 010405 organic chemistry organic chemicals Enantioselective synthesis food and beverages General Chemistry Combinatorial chemistry 0104 chemical sciences Allyl Compounds chemistry Intramolecular force Functional group Chirality (chemistry) Oxidation-Reduction |
| Popis: | An asymmetric Ni-catalyzed reductive cross-coupling has been developed to prepare enantioenriched allylic silanes. This enantioselective reductive alkenylation proceeds under mild conditions and exhibits good functional group tolerance. The chiral allylic silanes prepared here undergo a variety of stereospecific transformations, including intramolecular Hosomi-Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of chirality. |
| Databáze: | OpenAIRE |
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