Durability of Sirolimus for Lymphangioleiomyomatosis
| Autor: | Shiwan K. Shah, Jose Valle, Vincent G. Valentine, Lola Carrete, Alexandra N. Martirossian |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Lung Neoplasms Reproductive age Gastroenterology 03 medical and health sciences 0302 clinical medicine Chylous effusion hemic and lymphatic diseases Internal medicine Chylothoraces medicine Humans 030212 general & internal medicine Lymphangioleiomyomatosis Lung function Sirolimus Lung Antibiotics Antineoplastic business.industry General Medicine respiratory system medicine.disease Magnetic Resonance Imaging Pleural Effusion medicine.anatomical_structure 030228 respiratory system Female business Tomography X-Ray Computed medicine.drug |
| Zdroj: | The American journal of the medical sciences. 354(6) |
| ISSN: | 1538-2990 |
| Popis: | Lymphangioleiomyomatosis (LAM), a rare, multisystem disorder primarily affecting women of reproductive age, is characterized by cystic-appearing lung lesions, progressive loss of lung function, chylous effusions and renal angiomyolipomas. Sirolimus, an mammalian target of rapamycin inhibitor, has been shown to stabilize lung function, reduce symptoms and resolve chylous effusions in the short term for patients with LAM. Herein, we report a premenopausal female with LAM who experienced complete and durable resolution of her chylothoraces with significant and sustained improvement in lung function on sirolimus. |
| Databáze: | OpenAIRE |
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