The Effect of Depression on Health-Related Quality of Life Is Mediated by Fatigue in Persons with Multiple Sclerosis
| Autor: | Andrew T. Chan, Vladeta Ajdacic-Gross, Viktor von Wyl, Christian P. Kamm, Marco Kaufmann, Chiara Zecca, Jens Kuhle, Claudio Gobbi, Jürg Kesselring, Zina-Mary Manjaly, Pasquale Calabrese, Stephanie Rodgers, Anke Salmen, Nina Steinemann |
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| Přispěvatelé: | University of Zurich, Rodgers, Stephanie |
| Rok vydání: | 2021 |
| Předmět: |
Quality of life
11549 Institute of Implementation Science in Health Care Neurosciences. Biological psychiatry. Neuropsychiatry 610 Medicine & health multiple sclerosis quality of life depression fatigue longitudinal Article Depressive symptomatology Multiple sclerosis 03 medical and health sciences 0302 clinical medicine medicine 030212 general & internal medicine Depression (differential diagnoses) Fatigue Health related quality of life business.industry Depression General Neuroscience Longitudinal 2800 General Neuroscience Cognition 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) medicine.disease humanities Fatigue impact scale 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics business 610 Medizin und Gesundheit Psychosocial 030217 neurology & neurosurgery RC321-571 Clinical psychology |
| Zdroj: | Rodgers, Stephanie; Manjaly, Zina-Mary; Calabrese, Pasquale; Steinemann, Nina; Kaufmann, Marco; Salmen, Anke; Chan, Andrew; Kesselring, Jürg; Kamm, Christian P.; Kuhle, Jens; Zecca, Chiara; Gobbi, Claudio; von Wyl, Viktor; Ajdacic-Gross, Vladeta (2021). The Effect of Depression on Health-Related Quality of Life Is Mediated by Fatigue in Persons with Multiple Sclerosis. Brain Sciences, 11(6) MDPI 10.3390/brainsci11060751 Brain Sciences Brain Sciences, 11 (6) Brain Sciences; Volume 11; Issue 6; Pages: 751 Brain Sciences, Vol 11, Iss 751, p 751 (2021) |
| DOI: | 10.48350/157657 |
| Popis: | The interrelations between fatigue, depression and health-related quality of life (HRQoL) in persons with multiple sclerosis (PwMS) are complex, and the directionality of the effects is unclear. To address this gap, the current study used a longitudinal design to assess direct and indirect effects of fatigue and depression on HRQoL in a one-year follow-up survey. A sample of 210 PwMS from the nationwide Swiss MS Registry was used. HRQoL was assessed using the European Quality of Life 5-Dimension 5-Level questionnaire. Path analysis on HRQoL, with fatigue and depression as predictors, was applied. Fatigue was measured by the Modified Fatigue Impact Scale (MFIS), including physical, cognitive and psychosocial subscales, and non-somatic depressive symptomatology was examined with the Beck Depression Inventory-Fast Screen (BDI-FS). Fatigue acted as a fully mediating variable (B = −0.718, SE = 0.253) between non-somatic depressive symptomatology and HRQoL. This indirect effect became apparent in the physical (B = −0.624, SE = 0.250), psychosocial (B = −0.538, SE = 0.256) and cognitive subscales (B = −0.485, SE = 0.192) of fatigue. In contrast, non-somatic depressive symptomatology did not act as a mediator. Our findings provide novel and clinically relevant longitudinal evidence showing that the debilitating effect of non-somatic aspects of depression on HRQoL was fully mediated and therefore explainable via fatigue. Brain Sciences, 11 (6) |
| Databáze: | OpenAIRE |
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