The drug-transporter gene MDR1 C3435T and G2677T/A polymorphisms and the risk of multidrug-resistant epilepsy in Turkish children
Autor: | Mehmet Güven, Mehmet Seven, Adnan Yuksel, Selin Unal, Gozde Yesil, Bahadir Batar |
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Přispěvatelé: | YEŞİL, GÖZDE |
Rok vydání: | 2013 |
Předmět: |
Male
Risk ATP Binding Cassette Transporter Subfamily B Adolescent Turkey MDR1 Drug resistance Polymorphism Single Nucleotide Article Epilepsy Gene Frequency Genotype Genetics medicine Humans ATP Binding Cassette Transporter Subfamily B Member 1 Polymorphism Child Molecular Biology Allele frequency Genetic Association Studies P-glycoprotein biology Haplotype Infant General Medicine medicine.disease Drug Resistance Multiple Multiple drug resistance Haplotypes Child Preschool biology.protein P-gp Anticonvulsants Female Restriction fragment length polymorphism Polymorphism Restriction Fragment Length |
Zdroj: | Molecular Biology Reports |
ISSN: | 1573-4978 0301-4851 |
DOI: | 10.1007/s11033-013-2866-y |
Popis: | One-third of all individuals with epilepsy are resistant to antiepileptic drug (AED) treatment. Antiepileptic treatment response has been suggested to be modulated by genetic polymorphisms of drug efflux transporters. Several polymorphic variants within the multidrug resistance 1 (MDR1) gene, which encodes the major transmembrane efflux transporter P-glycoprotein, have been proposed to be associated with AED resistance in epilepsy patients. The aim of this study was to evaluate the effect of C3435T and G2677T/A polymorphisms of MDR1 on AED resistance in Turkish children with epilepsy. MDR1 C3435T and G2677T/A were genotyped in 152 patients with epilepsy, classified as drug-resistant in 69 and drug-responsive in 83. Genotypes of the C3435T and G2677T/A polymorphisms were determined by polymerase chain reaction followed by restriction fragment length polymorphism. Genotype and allele frequencies of C3435T and G2677T/A polymorphisms of the MDR1 gene did not differ between drug-resistant and drug-responsive epilepsy patients. Our results suggest that MDR1 C3435T and G2677T/A polymorphisms are not associated with AED resistance in Turkish epileptic patients. To clarify the exact clinical implication of the MDR1 polymorphisms on the multidrug resistance in epilepsy, further investigations in various ethnic populations would be necessary. |
Databáze: | OpenAIRE |
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