Chikungunya on Kidney Transplant Recipients: Is It the Same?
| Autor: | Bruno de Melo Tavares, Tacilla Hs Andrade, Samuel Frota Cunha, Claudia Maria Costa de Oliveira, Sônia Leite da Silva, Evelyne Santana Girão, Márcia Uchoa Mota, Paula Fcbc Fernandes |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Arthritis 030230 surgery medicine.disease_cause Kidney transplant Virus 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Chikungunya Aged Retrospective Studies Transplantation business.industry virus diseases Febrile illness Retrospective cohort study Acute Kidney Injury Middle Aged medicine.disease Arthralgia Kidney Transplantation Chikungunya Fever Female 030211 gastroenterology & hepatology business |
| Zdroj: | Transplantation. 103:441-445 |
| ISSN: | 1534-6080 0041-1337 |
| Popis: | Chikungunya virus (CHIKV) infection is an acute febrile illness with polyarthralgia and arthritis. There are few data about CHIKV infection in kidney transplant recipients (KTR). We report the largest case series of CHIKV infection in this population.We retrospectively analyzed 32 cases of CHIKV infection in KTR between January 2016 and December 2017 at Hospital Universitário Walter Cantídio of Federal University of Ceará.All patients had been in endemic areas before the beginning of the symptoms. All presented arthralgia, 15 (46.9%) with joint inflammatory symptoms and 14 (43.8%) evolved to chronic arthralgia. Seven (21.9%) showed acute kidney injury (AKI) by Kidney Disease: Improving Global Outcomes criteria during the acute phase. Acute kidney injury was not related to prednisone use (odds ratio [OR], 0.3; 95% confidence interval [CI], 0.04-2.61, P = 0.3) nor chronic arthralgia (OR, 1.2; 95% CI, 0.2-8.4, P = 0.8) as well as male sex, chronic kidney disease and older than 60 years (OR, 1.7; 95% CI, 0.3-10.3, P = 0.58; OR, 0.4; 95% CI, 0.1-2.7, P = 0.4; and OR, 2.1; 95% CI, 0.3-14.9, P = 0.45, respectively). Hospitalization was associated to AKI (OR, 44.0; 95% CI, 3.8-503.1; P = 0.002), probably due to diarrhea or dehydration. One patient died throughout the study, possibly unassociated with CHIKV infection.KTR with CHIKV infection have a clinical presentation and evolution similar to those seen in the general population. Kidney function is generally well preserved, with transitory graft dysfunction without negative impact after 3 months from the beginning of the symptoms. Previous costicosteroids use did not relate with AKI or chronic arthralgia. |
| Databáze: | OpenAIRE |
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