| Autor: |
Jun Wu, Nikolaos Kaplaneris, Julia Pöhlmann, Takuya Michiyuki, Binbin Yuan, Lutz Ackermann |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Angewandte Chemie International Edition |
| ISSN: |
1521-3773 |
| Popis: |
The prevalence of C-aryl glycosides in biologically active natural products and approved drugs has long motivated the development of efficient strategies for their selective synthesis. Cross-couplings have been frequently used, but largely relied on palladium catalyst with prefunctionalized substrates, while ruthenium-catalyzed C-aryl glycoside preparation has thus far proven elusive. Herein, we disclose a versatile ruthenium(II)-catalyzed meta-C-H glycosylation to access meta-C-aryl glycosides from readily available glycosyl halide donors. The robustness of the ruthenium catalysis was reflected by mild reaction conditions, outstanding levels of anomeric selectivity and exclusive meta-site-selectivity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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