Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial)
Autor: | Carla Martins, Luís Delgado, Carla Costa, Pedro Moreira, Diana Silva, João Cavaleiro Rufo, Tiago Montanha, Mariana Pinto, Marília Beltrão, Inês Paciência, Joana Carvalho, Andreia N. Pizarro, Ana Beatriz Graça Duarte, Rodrigo Villegas, Rita Simone Lopes Moreira, João Paulo Teixeira, André Moreira, Vanessa Garcia-Larsen, Oksana Sokhatska, Milton Severo |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Allostatic Load Exercise challenge Physical activity HEALTHY-SUBJECTS Inflammation Research & Experimental Medicine EXHALED BREATH CONDENSATE Article 03 medical and health sciences 0302 clinical medicine Immunity CARDIOMETABOLIC RISK Environmental health Exercise Challenge medicine Meal Pharmacology lcsh:R5-920 Science & Technology Physical inactivity INSULIN SENSITIVITY business.industry CARBOHYDRATE INGESTION 030229 sport sciences General Medicine Allostatic load MEDITERRANEAN MEAL INTERLEUKIN-6 RESPONSE 030104 developmental biology Medicine Research & Experimental YOUNG FATTY-ACIDS Genotoxicidade Ambiental medicine.symptom Physical Inactivity Mediterranean Meal lcsh:Medicine (General) business Life Sciences & Biomedicine |
Zdroj: | Contemporary Clinical Trials Communications, Vol 10, Iss, Pp 177-189 (2018) Contemporary Clinical Trials Communications |
ISSN: | 2451-8654 |
DOI: | 10.1016/j.conctc.2018.05.010 |
Popis: | Background: The effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2) the impact of an induced acute period of sedentary behavior on neuro-immune-endocrine status. Methods: /Design: This is a two steps clinical trial including: (a) randomized crossover clinical trial, comparing the effect a high-fat/low-nutrient dense meal, FFM, with an isoenergetic similar high-nutrient dense meal, MdM, in the immune response to an exercise challenge (EC) and (b) a pilot trial assessing the neuro-immune-endocrine change induced by acute decreasing by half the usual physical activity level. Results: A total of 46 participants (26 females), median aged 25 years were included. Of those 39-completed protocol, including overweight, physical active and inactive and participants with asthma. There were no differences in the EC between interventions. Dietary factors and physical activity were closely monitored during interventions and kept similar. During physical inactivity induction, 31% reached the target of 50% reduction in mean step number and 77% reached a 30% reduction. Conclusion: The use of a pre-exercise meal to modulate immune response and the understanding of the immunological impact of physical inactivity might help to establish future recommendations on how to practice exercise in a safer way and to recognize the potential impact of inactivity. Keywords: Allostatic load, Physical inactivity, Meal, Exercise challenge |
Databáze: | OpenAIRE |
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