The effect of hyaluronic acid-carboxymethylcellulose in reducing adhesion reformation in rabbits
| Autor: | Kazuo Satoh, H Osada, Ikuo Tsunoda, Tom Kiyoshi Fujii, Katsuo Tsubata, M Minai |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Microsurgery medicine.medical_treatment Adhesion (medicine) Biocompatible Materials Tissue Adhesions 030204 cardiovascular system & hematology Biochemistry Lesion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Postoperative Complications Laparotomy Hyaluronic acid medicine Animals Hyaluronic Acid Lagomorpha biology business.industry Biochemistry (medical) Membranes Artificial Cell Biology General Medicine Postoperative adhesion medicine.disease biology.organism_classification Surgery medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Abdomen Female Rabbits medicine.symptom business |
| Zdroj: | The Journal of international medical research. 27(6) |
| ISSN: | 0300-0605 |
| Popis: | The effect of hyaluronic acid-carboxymethylcellulose film (Seprafilm®)* in reducing postoperative adhesion formation was examined in a rabbit induced-adhesion model. During laparotomy, the ileocaecal region was mechanically and chemically abraded to induce lesions. After a 28-day recovery period, adhesions were lysed by microsurgery and Seprafilm® was applied to the lysed lesion in 10 rabbits and six rabbits received physiological saline. A third laparotomy was performed 10 – 14 days later and the area of adhesion reformation was compared to that found prior to application of test materials. The area of adhesion reformation with Seprafilm® decreased to (mean ± standard deviation) 11.71 ± 10.97% of the originally lysed lesion and, the area was significantly reduced compared with controls treated with physiological saline. These results suggest that the use of Seprafilm® may be a valuable new anti-adhesion material for abdominal or pelvic surgery and may be superior to existing anti-adhesion materials and techniques. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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