Macrophage immunoregulatory pathways in tuberculosis
| Autor: | Larry S. Schlesinger, Bin Ni, Murugesan V. S. Rajaram, Claire E. Dodd |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Immunology
Context (language use) Inflammation Article Mycobacterium tuberculosis Immune system Macrophages Alveolar medicine Humans Immunology and Allergy Macrophage Lung Tuberculosis Pulmonary Innate immune system biology Pattern recognition receptor Macrophage Activation biology.organism_classification Immunity Innate MicroRNAs Gene Expression Regulation Receptors Pattern Recognition Host-Pathogen Interactions Alveolar macrophage Cytokines medicine.symptom |
| Zdroj: | Seminars in Immunology. 26:471-485 |
| ISSN: | 1044-5323 |
| Popis: | Macrophages, the major host cells harboring Mycobacterium tuberculosis (M.tb), are a heterogeneous cell type depending on their tissue of origin and host they are derived from. Significant discord in macrophage responses to M.tb exists due to differences in M.tb strains and the various types of macrophages used to study tuberculosis (TB). This review will summarize current concepts regarding macrophage responses to M.tb infection, while pointing out relevant differences in experimental outcomes due to the use of divergent model systems. A brief description of the lung environment is included since there is increasing evidence that the alveolar macrophage (AM) has immunoregulatory properties that can delay optimal protective host immune responses. In this context, this review focuses on selected macrophage immunoregulatory pattern recognition receptors (PRRs), cytokines, negative regulators of inflammation, lipid mediators and microRNAs (miRNAs). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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