The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape
| Autor: | Begoña Dobon, Jaume Bertranpetit, Isis Ricaño-Ponce, Hisham Y. Hassan, David Comas, Pierre Luisi, Cisca Wijmenga, Hafid Laayouni, Hanan Tahir, Alexandra Zhernakova, Mihai G. Netea |
|---|---|
| Přispěvatelé: | Netherlands Organization for Scientific Research, European Research Council, Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Population
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] Ethnic group Black People North africa FARMER POPULATIONS Human genetic variation Polymorphism Single Nucleotide Article MALARIA POOL Genètica de poblacions humanes -- Àfrica del Nord Genetic variation HISTORY MULTIPLE parasitic diseases East africa Cluster Analysis Humans 10. No inequality education COMMON 2. Zero hunger Genetics Principal Component Analysis education.field_of_study Multidisciplinary Geography SAHEL Genetic Variation Host defence ASSOCIATION Africa Eastern 15. Life on land EVOLUTION ADMIXTURE Genetics Population Genetic structure |
| Zdroj: | Scientific Reports, 5 Digital.CSIC. Repositorio Institucional del CSIC instname Scientific Reports Scientific Reports, 5:09996. Nature Publishing Group Recercat. Dipósit de la Recerca de Catalunya Europe PubMed Central |
| ISSN: | 2045-2322 |
| Popis: | Trabajo presentado en la XV Jornada de Biología Evolutiva, celebrada en Barcelona el 23 de junio de 2015. East Africa is a strategic region to study human genetic diversity due to the presence of ethnically, linguistically, and geographically diverse populations. Here, we provide new insight into the genetic history of populations living in the Sudanese region of East Africa by analysing nine ethnic groups belonging to three African linguistic families: Niger-Kordofanian, Nilo-Saharan and Afro-Asiatic. A total of 500 individuals were genotyped for 200,000 single-nucleotide polymorphisms. Principal component analysis, clustering analysis using ADMIXTURE, FST statistics, and the three*population test were used to investigate the underlying genetic structure and ancestry of the different ethnolinguistic groups. Our analyses revealed a genetic component for Sudanese Nilo*Saharan speaking groups (Darfurians and part of Nuba populations) related to Nilotes of South Sudan, but not to other Sudanese populations or other sub*Saharan populations. Populations inhabiting the North of the region showed close genetic affinities with North Africa, with a component that could be remnant of North Africans before the migrations of Arabs from Arabia. In addition, we found very low genetic distances between populations in genes important for anti*malarial and anti-bacterial host defence, suggesting similar selective pressures on these genes and stressing the importance of considering functional pathways to understand the evolutionary history of populations. |
| Databáze: | OpenAIRE |
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