Primary angiitis of the spinal cord presenting as a conus mass: long-term remission
| Autor: | R. John Hurlbert, Mark E. Hudon, Douglas W. Zochodne, Nili R. Katz, Arunee Bhibhatbhan, Arthur W. Clark |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Vasculitis Pathology medicine.medical_specialty Time Factors Biopsy Central nervous system Diagnosis Differential Lesion medicine Humans Antineoplastic Agents Alkylating Cyclophosphamide Aged Spinal Neoplasms medicine.diagnostic_test business.industry Vascular disease Remission Induction Magnetic resonance imaging Middle Aged Spinal cord medicine.disease Magnetic Resonance Imaging Conus medullaris medicine.anatomical_structure Spinal Cord Female Surgery Neurology (clinical) medicine.symptom business |
| Zdroj: | Surgical Neurology. 66:622-625 |
| ISSN: | 0090-3019 |
| DOI: | 10.1016/j.surneu.2006.01.023 |
| Popis: | Background Primary angiitis of the central nervous system (CNS) is a rare vasculitic disorder that typically involves the brain and, less frequently, the spinal cord without involvement of the blood vessels outside the CNS. Case Description We present a case of a 52-year-old woman who developed a conus syndrome linked to an enhancing mass of her lower thoracic spinal cord, lumbar cord, and conus. Spinal cord biopsy performed for diagnostic purposes in the setting of progressive neurological deficit confirmed angiitis of the spinal cord. Therapy with steroid and cyclophosphamide was associated with long-term (3 years) clinical and imaging remission of the lesion. Conclusions The prognosis of primary CNS angiitis is dismal with most cases progressing to death. Long-term remission is unusual. Aggressive therapy with steroid and cytotoxic agents may improve survival. |
| Databáze: | OpenAIRE |
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