The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models
Autor: | Klaus Berger, Volker Arolt, Walter Heindel, Heike Wersching, Bernhard T. Baune, Ashley Gilmour, Michael J Stuart |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
medicine.medical_specialty
Hypothalamo-Hypophyseal System Models Neurological Statistics as Topic Pituitary-Adrenal System Disease Review Bioinformatics endothelial dysfunction Cellular and Molecular Neuroscience subtypes of depression cardiovascular disease Risk Factors Internal medicine medicine Dementia Humans Endothelial dysfunction Biological Psychiatry Depression (differential diagnoses) biological mechanisms Inflammation Depressive Disorder Incidence medicine.disease Psychiatry and Mental health Endocrinology Cross-Sectional Studies Schizophrenia Cardiovascular Diseases Behavioral medicine Arterial stiffness Psychopharmacology Endothelium Vascular Inflammation Mediators Psychology |
Zdroj: | Translational Psychiatry |
ISSN: | 2158-3188 |
Popis: | A compelling association has been observed between cardiovascular disease (CVD) and depression, suggesting individuals with depression to be at significantly higher risk for CVD and CVD-related mortality. Systemic immune activation, hypothalamic–pituitary–adrenal (HPA) axis hyperactivity, arterial stiffness and endothelial dysfunction have been frequently implicated in this relationship. Although a differential epidemiological association between CVD and depression subtypes is evident, it has not been determined if this indicates subtype specific biological mechanisms. A comprehensive systematic literature search was conducted using PubMed and PsycINFO databases yielding 147 articles for this review. A complex pattern of systemic immune activation, endothelial dysfunction and HPA axis hyperactivity is suggestive of the biological relationship between CVD and depression subtypes. The findings of this review suggest that diagnostic subtypes rather than a unifying model of depression should be considered when investigating the bidirectional biological relationship between CVD and depression. The suggested model of a subtype-specific biological relationship between depression and CVDs has implications for future research and possibly for diagnostic and therapeutic processes. |
Databáze: | OpenAIRE |
Externí odkaz: |