Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers?
Autor: | Frans Martens, Xiaoping Yang, Jesper Vilandt, Mogens Madsen, Knud T. Nielsen, Susan H. Gawel, Michael Klærke, Ib Jarle Christensen, Thore Hillig, Gerard J. Davis, Michael Wilhelmsen, Anne Meike Heijboer, Søren Laurberg, Lars N. Jorgensen, Hans Jørgen Nielsen |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty Protein biomarkers Colorectal cancer Immunology Malignancy Diagnostic Colonoscopy Gastroenterology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Internal medicine medicine cancer Immunology and Allergy endoscopy Original Research medicine.diagnostic_test business.industry biomarkers Cancer protein biomarkers medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Blood proteins Colon cancer Endoscopy 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business |
Zdroj: | Biomarkers in Cancer, Vol 10 (2018) Wilhelmsen, M, Christensen, I J, Jørgensen, L N, Madsen, M R, Vilandt, J, Hillig, T, Klærke, M, Nielsen, K T, Laurberg, S, Gawel, S, Yang, X, Davis, G, Heijboer, A M, Martens, F & Nielsen, H J 2018, ' Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers? ', Biomarkers in Cancer, vol. 10 . https://doi.org/10.1177/1179299X18776974 Wilhelmsen, M, Christensen, I J, Jørgensen, L N, Madsen, M R, Vilandt, J, Hillig, T, Klærke, M, Nielsen, K T, Laurberg, S, Gawel, S, Yang, X, Davis, G, Heijboer, A M, Martens, F & Nielsen, H J 2018, ' Clean Colorectum at Diagnostic Colonoscopy : Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers? ', Biomarkers in Cancer, vol. 10 . https://doi.org/10.1177/1179299X18776974 Biomarkers in Cancer |
Popis: | Introduction:Most of the subjects undergoing diagnostic colonoscopy do not have neoplastic bowel lesions. Potentially, some of the symptoms may therefore be caused by extracolonic malignancy, and subjects with persisting symptoms may need subsequent examinations. Blood-based, cancer-associated biomarkers may aid in directing the examinations for other specific malignant diseases.Methods:EDTA plasma samples available from a previous prospective study of subjects undergoing diagnostic colonoscopy were used for analysis of 18 protein biomarkers. The study population of 3732 subjects included 400 patients with colorectal cancer (CRC) and 177 patients with extracolonic malignancies. Univariable analysis of the association of specific biomarkers and extracolonic cancers included those with 10 or more cases. Subsequently, reduced models of 4 or 6 biomarkers, respectively, were established by choosing those with the highest likelihood; age and sex were included as well.Results:Univariable analyses showed that CyFra21-1 had an area under curve (AUC) of 0.87 for lung cancers (n = 33), CA19-9 had an AUC of 0.85 for pancreatic cancer (n = 22), CA125 had an AUC of 0.95 for ovary cancer (n = 16), B2M had an AUC of 0.81 for non-Hodgkin lymphoma (n = 12), and total prostate-specific antigen had an AUC of 0.99 for prostate cancer (n = 10). The multivariable analysis of 4 or 6 biomarkers plus age and sex as explanatory variables showed AUCs of 0.82 to 0.85 both for extracolonic cancers and CRC. The 4 biomarkers included in the model for detection of extracolonic cancers were CA125, hsCRP, CA19-9, and CyFra21-1; the 2 additional for the 6 biomarkers model were CEA and Galectin-3. Similarly, the 4 biomarkers included in the model for detection of CRC were CEA, CyFra21-1, Ferritin, and HE4; the two additional for the 6 biomarkers model were hsCRP and Pepsinogen 2.Conclusions:Results of this study indicate that it may be possible to detect subjects that have an increased risk of extracolonic cancer following a colonoscopy without findings of neoplastic lesions. Combinations of various protein biomarkers may direct subsequent examination after colonoscopy with clean colorectum. The results, although preliminary, may form the basis for additional research directed both for primary examinations of subjects with symptoms of malignancy and subsequent examinations after colonoscopy. |
Databáze: | OpenAIRE |
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