Experimental exposure to wood-smoke particles in healthy humans: effects on markers of inflammation, coagulation, and lipid peroxidation

Autor:	Gerd Sallsten, Lena Andersson, Samar Basu, Lennart Stigendal, Linda Johansson, Pernilla Gustafson, Lars Barregard
Rok vydání:	2006
Předmět:	Adult Male Health Toxicology and Mutagenesis Wood smoke Inflammation Toxicology medicine.disease_cause Dinoprost Lipid peroxidation chemistry.chemical_compound Smoke Surveys and Questionnaires von Willebrand Factor medicine Coagulation (water treatment) Humans Particle Size Acute-Phase Reaction Blood Coagulation Inhalation exposure Air Pollutants Inhalation Exposure Serum Amyloid A Protein Hematologic tests Factor VIII Hematologic Tests Middle Aged Smoke Inhalation Injury Particulate air pollution Wood Oxidative Stress chemistry Immunology Female Lipid Peroxidation medicine.symptom Oxidative stress Biomarkers
Zdroj:	Inhalation toxicology. 18(11)
ISSN:	1091-7691
Popis:	Particulate air pollution is known to increase cardiovascular morbidity and mortality. Proposed mechanisms underlying this increase include effects on inflammation, coagulation factors, and oxidative stress, which could increase the risk of coronary events and atherosclerosis. The aim of this study was to examine whether short-term exposure to wood smoke affects markers of inflammation, blood hemostasis, and lipid peroxidation in healthy humans. Thirteen subjects were exposed to wood smoke and clean air in a chamber during two 4-h sessions, 1 wk apart. The mass concentrations of fine particles at wood smoke exposure were 240-280 mug/m3, and number concentrations were 95,000-180,000/cm3. About half of the particles were ultrafine (100 nm). Blood and urine samples were taken before and after the experiment. Exposure to wood smoke increased the levels of serum amyloid A, a cardiovascular risk factor, as well as factor VIII in plasma and the factor VIII/von Willebrand factor ratio, indicating a slight effect on the balance of coagulation factors. Moreover, there was an increased urinary excretion of free 8-iso-prostaglandin2alpha, a major F2-isoprostane, though this was based on nine subjects only, indicating a temporary increase in free radical-mediated lipid peroxidation. Thus, wood-smoke particles at levels that can be found in smoky indoor environments seem to affect inflammation, coagulation, and possibly lipid peroxidation. These factors may be involved in the mechanisms whereby particulate air pollution affects cardiovascular morbidity and mortality. The exposure setup could be used to establish which particle characteristics are critical for the effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16bbed29ca30c054b26af32717a1f8b https://pubmed.ncbi.nlm.nih.gov/16864402 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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