Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California
| Autor: | Venice Servellita, Mary Kate Morris, Alicia Sotomayor-Gonzalez, Amelia S. Gliwa, Erika Torres, Noah Brazer, Alicia Zhou, Katherine T. Hernandez, Madeline Sankaran, Baolin Wang, Daniel Wong, Candace Wang, Yueyuan Zhang, Kevin R. Reyes, Dustin Glasner, Xianding Deng, Jessica Streithorst, Steve Miller, Edwin Frias, Mary Rodgers, Gavin Cloherty, John Hackett, Carl Hanson, Debra Wadford, Susan Philip, Scott Topper, Darpun Sachdev, Charles Y. Chiu |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Adult Male COVID-19 Vaccines Adolescent Immunology Genome Viral Antibodies Viral Applied Microbiology and Biotechnology Microbiology Cohort Studies Young Adult Genetics Humans BNT162 Vaccine Phylogeny Aged Whole Genome Sequencing SARS-CoV-2 Vaccination COVID-19 Cell Biology Middle Aged Viral Load Antibodies Neutralizing Mutation Female San Francisco |
| Zdroj: | Nature microbiology. 7(2) |
| ISSN: | 2058-5276 |
| Popis: | Associations between vaccine breakthrough cases and infection by different SARS coronavirus 2 (SARS-CoV-2) variants have remained largely unexplored. Here we analysed SARS-CoV-2 whole-genome sequences and viral loads from 1,373 persons with COVID-19 from the San Francisco Bay Area from 1 February to 30 June 2021, of which 125 (9.1%) were vaccine breakthrough infections. Vaccine breakthrough infections were more commonly associated with circulating antibody-resistant variants carrying ≥1 mutation associated with decreased antibody neutralization (L452R/Q, E484K/Q and/or F490S) than infections in unvaccinated individuals (78% versus 48%, P = 1.96 × 10 |
| Databáze: | OpenAIRE |
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