Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis
| Autor: | John S. Mort, Hiroomi Tateishi, Yasuo Iwata, Eunice R. Lee |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Cartilage Articular Male Pathology medicine.medical_specialty Cathepsin L Immunology Peripheral blood mononuclear cell Bone and Bones Arthritis Rheumatoid Pathogenesis Rheumatology Antibody Specificity Endopeptidases medicine Humans Immunology and Allergy Macrophage Pharmacology (medical) Aged Cathepsin Enzyme Precursors biology business.industry CD68 Middle Aged medicine.disease Cathepsins Immunohistochemistry Cysteine Endopeptidases Microscopy Electron Rheumatoid arthritis biology.protein Female business |
| Zdroj: | Arthritis & Rheumatism. 40:499-509 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.1780400316 |
| Popis: | Objective. To test the hypothesis that the proteinase cathepsin L is involved in the subchondral bone lesions found in chronic rheumatoid arthritis (RA). Methods. The medial tibial plateaus from 4 control cases and 30 patients diagnosed as having end-stage RA were examined immunochemically for cathepsin L. Results. RA lesions include large groups of mononuclear cells, many of which are rich in cathepsin L. Since these mononuclear cells contained the CD68 glycoprotein and, in the electron microscope, displayed an irregular cell surface, cytoplasmic vacuoles, lysosomes, and phagosomes, they were identified as belonging to the macrophage family. The lesions were classified into 2 main patterns, both displaying these cathepsin L—rich cells, which, in at least 1 of the 2, were closely associated with bone degradation. Conclusion. The cathepsin L—rich macrophages are sufficiently numerous to be considered a major factor in producing the erosion of subchondral bone found in chronic RA lesions. |
| Databáze: | OpenAIRE |
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