Benign breast disease and changes in mammographic breast density
Autor: | Mary Beth Terry, Laura Reimers, Ying Wei, Parisa Tehranifar, Karin B. Michels, Julie D. Flom, Piera M. Cirillo, Barbara A. Cohn, Mandy Goldberg |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
medicine.medical_specialty Adolescent Percent density Breast Neoplasms Benign breast disease First birth 03 medical and health sciences Breast Diseases Young Adult 0302 clinical medicine Breast cancer Pregnancy Risk Factors medicine Humans 030212 general & internal medicine Prospective Studies skin and connective tissue diseases Child Generalized estimating equation RC254-282 Breast Density Obstetrics business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Mammographic breast density medicine.disease Parity Risk factors for breast cancer 030220 oncology & carcinogenesis Cohort Female Breast disease business Research Article Follow-Up Studies Mammography |
Zdroj: | Breast Cancer Research : BCR Breast Cancer Research, Vol 23, Iss 1, Pp 1-9 (2021) |
ISSN: | 1465-542X 1465-5411 |
Popis: | BackgroundMammographic breast density (MBD) and benign breast disease (BBD) are two of the strongest risk factors for breast cancer. Understanding trends in MBD by age and parity in women with BBD is essential to the clinical management and prevention of breast cancer.MethodsUsing data from the Early Determinants of Mammographic Density (EDMD) study, a prospective follow-up study of women born in 1959–1967, we evaluated MBD in 676 women. We used linear regression with generalized estimating equations to examine associations between self-reported BBD and MBD (percent density, dense area, and non-dense area), assessed through a computer-assisted method.ResultsA prior BBD diagnosis (median age at diagnosis 32 years) was reported by 18% of our cohort. The median time from BBD diagnosis to first available study mammogram was 9.4 years (range 1.1–27.6 years). Women with BBD had a 3.44% higher percent MBD (standard error (SE) = 1.56,p-value = 0.03) on their first available mammogram than women without BBD. Compared with parous women without BBD, nulliparous women with BBD and women with a BBD diagnosis prior to first birth had 7–8% higher percent MBD (β= 7.25, SE = 2.43,p-valuep-value = 0.01, respectively), while there was no difference in MBD in women with a BBD diagnosis after the first birth (β= −0.22, SE = 2.40,p-value = 0.93).ConclusionWomen with self-reported BBD had higher mammographic breast density than women without BBD; the association was limited to women with BBD diagnosed before their first birth. |
Databáze: | OpenAIRE |
Externí odkaz: |