| Autor: |
Diane Damotte, Wolf-Herman Fridman, Catherine Sautès-Fridman, Bernhard Mlecnik, Stéphane Oudard, Olivier-Nicolas Pagès, Jean-François Régnard, Virginie Verkarre, Laure Gibault, Jean-François Fléjou, Aurélie Cazes, Jeremy Goc, Hanane Ouakrim, Lucile Crozet, Marc Riquet, Marie-Caroline Dieu-Nosjean, Audrey Lupo, Isabelle Cremer, Marco Alifano, Romain Remark |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.c.6521661.v1 |
| Popis: |
Purpose: If immune cells are involved in tumor surveillance and have a prognostic impact in most primary tumors, little is known about their significance in metastases. Because patients' survival is heterogeneous, even at metastatic stages, we hypothesized that immune cells may be involved in the control of metastases. We therefore characterized the tumor immune microenvironment and its prognostic value in colorectal and renal cell carcinoma (RCC) metastases, and compared it to primary tumors.Experimental Design: We analyzed by immunohistochemistry (n = 192) and qPCR (n = 32) the immune environments of colorectal carcinoma and RCC lung metastases.Results: Metastases from colorectal carcinoma and RCC have different immune infiltrates. Higher densities of DC-LAMP+ mature dendritic cells (P < 0.0001) and lower densities of NKp46+ NK cells (P < 0.0001) were observed in colorectal carcinoma as compared to RCC metastases, whereas densities of T cells were similar. High densities of CD8+ and DC-LAMP+ cells correlated with longer overall survival (OS) in colorectal carcinoma (P = 0.008) and shorter OS in RCC (P < 0.0001). High NK-cell densities were associated with improved survival in RCC (P = 0.002) but not in colorectal carcinoma. Densities of immune cells correlated significantly from primary to relapsing metastases for the same patient. A TH1 orientation was found in colorectal carcinoma metastases, whereas a heterogeneous immune gene expression was found in RCC metastases.Conclusions: Our results show a major prognostic value of the immune pattern (CD8+/DC-LAMP+ cell densities) in colorectal carcinoma and RCC, reproducible from primary to metastatic tumors, although with opposite clinical impacts, and highlight the role of the tumor cell in shaping its immune environment. Clin Cancer Res; 19(15); 4079–91. ©2013 AACR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
