Climacteric Status at the Age of 46: Impact on Metabolic Outcomes in Population-Based Study
| Autor: | Tapani Ebeling, Hannele Mäkelä, Juha Auvinen, Maarit Niinimäki, Eila T J Suvanto, Susanna M. Savukoski, Katri Puukka, Jari Jokelainen |
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| Rok vydání: | 2018 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Clinical Biochemistry Blood Pressure Biochemistry Body fat percentage Body Mass Index Cohort Studies 0302 clinical medicine Endocrinology Waist–hip ratio Testosterone 030212 general & internal medicine Prospective Studies Prospective cohort study Finland 030219 obstetrics & reproductive medicine Estrogen Replacement Therapy Alanine Transaminase gamma-Glutamyltransferase Middle Aged Postmenopause C-Reactive Protein Cholesterol Adipose Tissue Body Composition Female Menopause Climacteric medicine.medical_specialty Waist Context (language use) 03 medical and health sciences Internal medicine medicine Humans Aspartate Aminotransferases Muscle Skeletal Triglycerides business.industry Free androgen index Waist-Hip Ratio Biochemistry (medical) Cholesterol HDL Cholesterol LDL Perimenopause Premenopause Follicle Stimulating Hormone business Body mass index |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 104(7) |
| ISSN: | 1945-7197 |
| Popis: | CONTEXT Menopausal transition is associated with increased cardiovascular risks. Available data on the effect of earlier climacterium on these risks are limited. OBJECTIVE To compare cardiovascular risk-associated parameters at the ages of 14, 31, and 46 in relation to climacteric status at the age of 46. DESIGN, SETTING, AND PARTICIPANTS A prospective cohort study including 2685 women from the Northern Finland Birth Cohort 1966. MAIN OUTCOME MEASURES Follicle-stimulating hormone, body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), blood pressure (BP), body composition, cholesterol levels, testosterone (T) levels, free androgen index (FAI), high-sensitivity C-reactive protein (hs-CRP), and liver enzymes. RESULTS Women who were climacteric at the age of 46 had lower BMIs (P = 0.029), T levels (P = 0.018), and FAIs (P = 0.009) at the age of 31. At the age of 46, they had less skeletal muscle (P < 0.001), a higher fat percentage (P = 0.016), higher cholesterol levels [total cholesterol (P < 0.001), low-density lipoprotein cholesterol (P < 0.001), high-density lipoprotein cholesterol (HDL-C; P = 0.022), and triglycerides (P = 0.008)], and higher alanine aminotransferase (P = 0.023) and γ-glutamyltransferase (P < 0.001) levels compared with preclimacteric women. Waist circumference, WHR, BP, and hs-CRP levels did not differ between the groups. Of the climacteric women, 111/381 were using hormone-replacement therapy (HRT). In subanalysis that excluded the HRT users, triglycerides, HDL-C, and body fat percentage did not differ among the groups. CONCLUSIONS Earlier climacterium is associated with mainly unfavorable metabolic changes. |
| Databáze: | OpenAIRE |
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