Evaluation of Lenticulostriate Arteries Changes by 7 T Magnetic Resonance Angiography in Type 2 Diabetes
| Autor: | Ai Chida, Kuniaki Ogasawara, Makoto Sasaki, Yusuke Todate, Kan Nagasawa, Ikuko Uwano, Satoshi Yashiro, Yutaka Hasegawa, Yasushi Ishigaki, Hiroyuki Kameda |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Early detection Neuroimaging Type 2 diabetes 030204 cardiovascular system & hematology Magnetic resonance angiography 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Internal Medicine Medicine Humans Pathological Lenticulostriate arteries medicine.diagnostic_test business.industry Basal Ganglia Cerebrovascular Disease Biochemistry (medical) Diabetes Blood flow Middle Aged Control subjects medicine.disease Prognosis Small vessel disease Diabetes Mellitus Type 2 Cardiology Female Original Article Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Magnetic Resonance Angiography Follow-Up Studies |
| Zdroj: | Journal of Atherosclerosis and Thrombosis |
| ISSN: | 1880-3873 |
| Popis: | Aim Progress in neuroimaging techniques allows us to investigate the microvasculature characteristics including lenticulostriate arteries (LSA), which are closely associated with lacunar infarction. Because ischemic stroke is a more critical health problem in East Asian than in other populations, in order to clarify pathological changes underlying cerebral small vessel disease (SVD), we projected an imaging analysis of LSA using high-resolution brain magnetic resonance imaging (MRI) in middle-aged Japanese subjects with type 2 diabetes. Methods Twenty-five subjects with type 2 diabetes and 25 non-diabetic control subjects underwent 7 Tesla (7 T) brain MRI. The prevalences of SVD and LSA structural changes were determined in each group. Results SVD prevalence did not differ significantly between the type 2 diabetes and control groups. The average numbers of stems, as well as numbers of branches, of LSA were significantly smaller in diabetic subjects than non-diabetic control subjects. The signal intensity of LSA was markedly decreased, indicating reduced blood flow in type 2 diabetes. Conclusion In spite of the prevalence of SVD being similar, structural changes and decreased signal intensity of LSA were highly detected in diabetic subjects compared with non-diabetic controls, suggesting that 7 T MRA enables us to determine LSA impairment prior to the development of SVD. Early detection of LSA impairment allows us earlier interventions aimed at the prevention of atherosclerotic events. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|