Sonic hedgehog signaling is required for sympathetic nervous system development
| Autor: | Yuka Morikawa, Emily Maska, Heather M. Brody, Peter Cserjesi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Nervous system
Sympathetic nervous system Sympathetic Nervous System animal structures Tyrosine 3-Monooxygenase Neurogenesis Biology Mice Ganglia Sensory Tubulin Ganglia Spinal medicine Animals Hedgehog Proteins Sonic hedgehog Mice Knockout Neurons Tyrosine hydroxylase General Neuroscience Sympathetic trunk beta-Galactosidase Immunohistochemistry Hedgehog signaling pathway Autonomic nervous system medicine.anatomical_structure embryonic structures biology.protein Neuroglia Neuroscience |
| Zdroj: | NeuroReport. 20:684-688 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/wnr.0b013e32832a1e6d |
| Popis: | Sonic hedgehog (Shh) plays critical roles during nervous system development, yet little is known about its function in the sympathetic nervous system. Using a mouse Shh null line, we examined the roles of Shh during SNS development. Loss of Shh did not prevent formation of the sympathetic trunk, but the ganglia are hypoplastic and misspatterned. Neuronal differentiation was delayed in Shh mutant embryos showing that Shh is required for correct developmental timing in addition to its role in sympathetic nervous system patterning. Immunohistochemical analyses of the ganglia for expression of the pan-neuronal marker beta3-tubulin, the noradrenergic biosynthetic enzyme tyrosine hydroxylase and the glial marker B-FABP showed that Shh is not required for differentiation of sympathetic neurons or glia. |
| Databáze: | OpenAIRE |
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