Effect of corticosteroid on the acidosis of prolonged cardiopulmonary bypass
| Autor: | Melvin L. Moses, Louis Pierucci, Thomas F. Nealon, Kouichi Tokunaga, Allen L. Davies, Rudolph C. Camishion |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Hydrocortisone
medicine.drug_class Blood Pressure Heart-Lung Machine In Vitro Techniques Body weight Methylprednisolone law.invention Dogs law medicine Cardiopulmonary bypass Animals Mortality Survival rate Acidosis Mongrel dogs business.industry Metabolic acidosis medicine.disease Anesthesia Corticosteroid Surgery Blood Gas Analysis medicine.symptom business Blood Chemical Analysis |
| Zdroj: | Journal of Surgical Research. 6:354-360 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/s0022-4804(66)80051-3 |
| Popis: | Summary Total cardiopulmonary bypass at a flow rate of 50 ml. per kilogram of body weight per minute consistently produced metabolic acidosis in adult mongrel dogs. The acidosis was partially inhibited by pretreatment of the animals with large doses of corticosteroids. The pretreated animals showed a greater survival rate and a better postoperative clinical condition. Possible explanations for the effect of the steroids are discussed. |
| Databáze: | OpenAIRE |
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