High prevalence of nasal carriage of β-lactamase-negative ampicillin-resistantHaemophilus influenzaein healthy children in Korea
| Autor: | Yeon Ho Kang, Sang Hyub Lee, Sungkyoung Lee, Jae-Yon Yu, Jaehwa Lee, Songmee Bae |
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| Rok vydání: | 2012 |
| Předmět: |
Genotype
Epidemiology Microbial Sensitivity Tests Nose Amoxicillin-Potassium Clavulanate Combination medicine.disease_cause beta-Lactamases Microbiology Haemophilus influenzae Amp resistance Ampicillin Republic of Korea Prevalence medicine Humans Nasal carriage Child business.industry Amoxicillin Antimicrobial Original Papers Anti-Bacterial Agents Infectious Diseases Carriage Child Preschool Carrier State Epidemiological Monitoring business Ampicillin Resistance Cefaclor medicine.drug |
| Zdroj: | Epidemiol Infect |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268812001082 |
| Popis: | SUMMARYThis study investigated the carriage of antimicrobial resistantHaemophilus influenzaein 582 healthy children attending kindergarten or elementary school at four intervals over a 9-month period in Seoul, Korea. Diverse colonization patterns and a lower level of long-term persistent carriage byH. influenzaestatus were evident in this study. ColonizingH. influenzaeisolates showed a high rate of resistance to β-lactams including ampicillin (51·9%), cefaclor (52·1%), and amoxicillin/clavulanate (16·3%). Based on the ampicillin resistance mechanism,H. influenzaeisolates were categorized as β-lactamase-negative, ampicillin-susceptible (BLNAS) (48·1%), β-lactamase-positive, ampicillin-resistant (BLPAR) (22·6%), β-lactamase-negative, ampicillin-resistant (BLNAR) (22·8%), and β-lactamase-positive, amoxicillin/clavulanate-resistant (BLPACR) strains (6·5%). This study provides the first evidence of a high prevalence (22·8%) of BLNAR strains ofH. influenzaenasal carriage in healthy children attending kindergarten or the first 2 years of elementary school in Korea. The high carriage of these resistant strains in overcrowded urban settings may create reservoirs for development ofH. influenzae-resistant strains. |
| Databáze: | OpenAIRE |
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