Immunotherapy in Metastatic Mucosal Melanoma with Disseminated Intravascular Coagulation: A Case of Success
| Autor: | Rita Sousa, Daniel Da Silva Gomes, Rita Teixeira de Sousa, Dolores Lopez Presa, L. Costa, André Mansinho, Rita Luís, Paulo Luz, Soraia Lobo-Martins, Helena Luna Pais |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Disseminated intravascular coagulation medicine.medical_specialty Local excision business.industry medicine.medical_treatment Melanoma Immunology Mucosal melanoma Case Report Immunotherapy RC581-607 medicine.disease Primary tumor Internal medicine Cutaneous melanoma Disease remission medicine Immunology and Allergy Immunologic diseases. Allergy business |
| Zdroj: | Case Reports in Immunology Case Reports in Immunology, Vol 2021 (2021) |
| ISSN: | 2090-6617 2090-6609 |
| Popis: | Mucosal melanoma accounts for 1% of all melanomas. It is more aggressive than cutaneous melanoma, and local excision provides the best disease-free survival. The vast majority of patients eventually develop metastases, with a metastatic pattern independent of the primary tumor site. While studies show that BRAF and KIT inhibitors have a role in the management of these patients, the actual treatment focus is on immunotherapy. Herein is described the case of a 79-year-old woman with metastatic mucosal melanoma and bone marrow infiltration causing disseminated intravascular coagulation, who was treated with an immunotherapy combination (anti-CTLA-4 and anti-PD-1 antibodies), achieving complete disease remission. This is the third case of melanoma with disseminated intravascular coagulation at presentation and the second case treated with immunotherapy in the literature, but the only one achieving disease remission. |
| Databáze: | OpenAIRE |
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