Efficacy and safety of the combination therapy Pilogel/beta-blocker: interim results
| Autor: | Maas S, Ros Fe, De Heer Lj, De Keizer Rj |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Intraocular pressure medicine.medical_specialty Evening genetic structures Combination therapy medicine.medical_treatment Adrenergic beta-Antagonists Ocular hypertension Glaucoma Refraction Ocular Physiology (medical) Ophthalmology medicine Humans Multicenter Studies as Topic Intraocular Pressure Morning Aged Clinical Trials as Topic business.industry Pilocarpine Eye drop Pupil Middle Aged medicine.disease eye diseases Sensory Systems Betaxolol Circadian Rhythm Clinical trial Anesthesia Timolol Drug Therapy Combination Female Metipranolol Ocular Hypertension sense organs business Gels Glaucoma Open-Angle |
| Zdroj: | Documenta ophthalmologica. Advances in ophthalmology. 72(3-4) |
| ISSN: | 0012-4486 |
| Popis: | The interim results of a multicentered clinical trial with the combination therapy therapy Pilogel/topical beta-blocker (twice daily) in patients with primary open angle glaucoma or ocular hypertension are discussed. Six patients were treated with Pilogel and a topical beta-blocker for one month. Four out of six patients responded well to the combination therapy. Most patients experienced some difficulty in applying the gel and their eyelids stuck together on awakening. In two patients a superficial punctate keratitis was observed. We found an average decrease in intra-ocular pressure (IOP) of 22.5% 22.5 hours after Pilogel administration, but there was some tendency towards higher evening values compared to morning values. In view of the appearance of a corneal haze as described by Johnson et al. during long-term treatment, longer follow-up is necessary. |
| Databáze: | OpenAIRE |
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