Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy
| Autor: | Alena Gribko, Carsten Weiss, Miriam Filippi, Qiang Lu, Svenja Siemer, Désirée Wünsch, Guo-Bin Ding, Roland H. Stauber, Jan Hagemann, Aya Khamis, Marie Pierre Krafft, Arnaud Scherberich |
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| Přispěvatelé: | Institut Charles Sadron (ICS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2020 |
| Předmět: |
Life sciences
biology General Chemical Engineering Cancer therapy 02 engineering and technology Computational biology [CHIM.THER]Chemical Sciences/Medicinal Chemistry Review circulating tumor cells microbubbles Metastasis lcsh:Chemistry 03 medical and health sciences Circulating tumor cell biocompatibility ddc:570 medicine metastasis General Materials Science Liquid biopsy 030304 developmental biology 0303 health sciences nanotechnology Cancer 021001 nanoscience & nanotechnology medicine.disease Primary tumor nanomedicine 3. Good health Tumor detection lcsh:QD1-999 Nanomedicine 0210 nano-technology |
| Zdroj: | Nanomaterials Nanomaterials, Vol 10, Iss 2, p 383 (2020) Nanomaterials, MDPI, 2020, ⟨10.3390/nano10020383⟩ Nanomaterials, 10 (2), 383 |
| ISSN: | 2079-4991 |
| DOI: | 10.3390/nano10020383⟩ |
| Popis: | International audience; Nanomaterials have great potential for the prevention and treatment of cancer. Circulating tumor cells (CTCs) are cancer cells of solid tumor origin entering the peripheral blood after detachment from a primary tumor. The occurrence and circulation of CTCs are accepted as a prerequisite for the formation of metastases, which is the major cause of cancer-associated deaths. Due to their clinical significance CTCs are intensively discussed to be used as liquid biopsy for early diagnosis and prognosis of cancer. However, there are substantial challenges for the clinical use of CTCs based on their extreme rarity and heterogeneous biology. Therefore, methods for effective isolation and detection of CTCs are urgently needed. With the rapid development of nanotechnology and its wide applications in the biomedical field, researchers have designed various nano-sized systems with the capability of CTCs detection, isolation, and CTCs-targeted cancer therapy. In the present review, we summarize the underlying mechanisms of CTC-associated tumor metastasis, and give detailed information about the unique properties of CTCs that can be harnessed for their effective analytical detection and enrichment. Furthermore, we want to give an overview of representative nano-systems for CTC isolation, and highlight recent achievements in microfluidics and lab-on-a-chip technologies. We also emphasize the recent advances in nano-based CTCs-targeted cancer therapy. We conclude by critically discussing recent CTC-based nano-systems with high therapeutic and diagnostic potential as well as their biocompatibility as a practical example of applied nanotechnology. |
| Databáze: | OpenAIRE |
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