The role of brain noradrenaline in cortical activation and behavior: A study of lesions of the locus coeruleus, medial thalamus and hippocampus-neocortex and of muscarinic blockade in the rat
| Autor: | C.H. Vanderwolf, Glen B. Baker |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Biogenic Amines Scopolamine Thalamus Central nervous system Hippocampus Muscarinic Antagonists Hippocampal formation Cholinergic Antagonists Norepinephrine Behavioral Neuroscience medicine Animals Oxidopamine Chromatography High Pressure Liquid Brain Chemistry Cerebral Cortex Neocortex Behavior Animal Chemistry Rats medicine.anatomical_structure Cerebral cortex Sympatholytics Locus coeruleus Locus Coeruleus Neuroscience Psychomotor Performance medicine.drug |
| Zdroj: | Behavioural Brain Research. 78:225-234 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/0166-4328(95)00253-7 |
| Popis: | Local injection of 6-hydroxydopamine in the locus coeruleus resulted in a 90% depletion of noradrenaline (NA) in the cerebral cortex as assessed by high-pressure liquid chromatography. This NA depletion had no effect on scopolamine-resistant hippocampal rhythmical slow activity and only an occasional effect on scopolamine-resistant neocortical low voltage fast activity. However, NE depletion resulted in a slight deficit in a behavioral swim-to-platform test and increased the deficit produced on the test by systemic treatment with scopolamine. Large surgical lesions of the medial thalamus or hippocampal formation plus posterior neocortex greatly increased the behavioral deficit produced by scopolamine. It is concluded that ascending noradrenergic projections play only a modest and possibly indirect role in the control of electrocortical activation and that a number of different brain lesions increase the behavioral impairment produced by central muscarinic blockade. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect