Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder
| Autor: | Hongwei Sun, Simon S.Y. Lui, Eric F.C. Cheung, Yan-Yu Wang, Ke Ni, John Suckling, Ying-min Zou, Yi Wang, Raymond C.K. Chan, Xue Tian |
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| Přispěvatelé: | Suckling, John [0000-0002-5098-1527], Apollo - University of Cambridge Repository |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-diagnostic Bipolar Disorder Theory of Mind Major depressive disorder 03 medical and health sciences Executive Function Young Adult 0302 clinical medicine Prevalence of mental disorders Theory of mind medicine Humans Cognitive Dysfunction Bipolar disorder Psychiatry Biological Psychiatry Depressive Disorder Major Cognition medicine.disease 030227 psychiatry Facial Expression Psychiatry and Mental health Affect Social Perception Schizophrenia Network analysis Female Analysis of variance Psychology 030217 neurology & neurosurgery Clinical psychology Executive dysfunction |
| DOI: | 10.17863/cam.18356 |
| Popis: | Background Although Theory of Mind (ToM) impairment has been observed in patients with a wide range of mental disorders, the similarity and uniqueness of these deficits across diagnostic groups has not been thoroughly investigated. Methods We recruited 35 participants with schizophrenia (SCZ), 35 with bipolar disorder (BD), 35 with major depressive disorder (MDD), and 35 healthy controls in this study. All participants were matched in age, gender proportion and IQ estimates. The Yoni task, capturing both the cognitive and affective components of ToM at the first- and second-order level was administered. Repeated-measure ANOVA and MANOVA were conducted to compare the group differences in ToM performance. A network was then constructed with ToM performances, psychotic and depressive symptoms, and executive function as nodes exploring the clinical correlates of ToM. Results Overall, ToM impairments were observed in all patient groups compared with healthy controls, with patients with SCZ performing worse than those with BD. In second-order conditions, patients with SCZ and MDD showed deficits in both cognitive and affective conditions, while patients with BD performed significantly poorer in cognitive conditions. Network analysis showed that second-order affective ToM performance was associated with psychotic and depressive symptoms as well as executive dysfunction, while second-order affective ToM performance and negative symptoms showed relatively high centrality in the network. Conclusions Patients with SCZ, MDD and BD exhibited different types and severity of impairments in ToM sub-components. Impairment in higher-order affective ToM appears to be closely related to clinical symptoms in both psychotic and affective disorders. |
| Databáze: | OpenAIRE |
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