Perspective: Water-Filtered Infrared-A-Radiation (wIRA) – Novel Treatment Options for Chlamydial Infections?
| Autor: | Nicole Borel, Jasmin Kuratli |
|---|---|
| Přispěvatelé: | University of Zurich, Borel, Nicole |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
wIRA/VIS medicine.medical_specialty lcsh:QR1-502 10184 Institute of Veterinary Pathology Chlamydia trachomatis wound healing medicine.disease_cause Microbiology 2726 Microbiology (medical) lcsh:Microbiology 03 medical and health sciences CHLAMYDIAL INFECTIONS medicine 030304 developmental biology 0303 health sciences Chlamydia 030306 microbiology business.industry 2404 Microbiology Treatment options alternative treatment strategies medicine.disease Dermatology Wound infection wIRA irradiation Trachoma Perspective 570 Life sciences biology wound infection Wound healing business Ex vivo |
| Zdroj: | Frontiers in Microbiology Frontiers in Microbiology, Vol 10 (2019) |
| ISSN: | 1664-302X |
| Popis: | Water-filtered infrared-A-radiation (wIRA) is a promising therapeutic method, which is particularly used as supportive treatment for wound closure, and wound infection treatment and prevention. High penetration properties of the heat field and beneficial effects on wound healing processes predispose wIRA irradiation to be a non-invasive treatment method for bacterial infections in superficial tissues. Since Chlamydia trachomatis still represents the leading cause of infectious blindness in third world countries (WHO http://www.who.int/topics/trachoma/en/) and wIRA displays beneficial effects on chlamydial infections in vitro without inducing cellular damage in ex vivo eye models and also shows beneficial effects on wound healing, this irradiation technique might represent a promising future treatment for trachoma patients. To this end, further studies investigating shorter irradiation times or irradiation of Chlamydia in chronic infections [the chlamydial stress response (Bavoil, 2014)] as well as safety studies in animal models should clearly be performed. |
| Databáze: | OpenAIRE |
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