Current advances in drug discovery for Chagas disease
| Autor: | Daniela Hartmann Jornada, Man Chin Chung, Rafael Consolin Chelucci, Cauê Benito Scarim, Jean Leandro dos Santos, Letícia Yamawaka de Almeida |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chagas disease medicine.medical_specialty Chemistry Pharmaceutical Trypanosoma cruzi 030106 microbiology Disease Structure-Activity Relationship 03 medical and health sciences Parasitic Sensitivity Tests Drug Discovery medicine Animals Humans Chagas Disease Nifurtimox Intensive care medicine Pharmacology Bone marrow depression Dose-Response Relationship Drug Molecular Structure biology Drug discovery Chemistry Organic Chemistry General Medicine medicine.disease biology.organism_classification Trypanocidal Agents 030104 developmental biology Benznidazole Neglected tropical diseases medicine.drug |
| Zdroj: | European Journal of Medicinal Chemistry. 155:824-838 |
| ISSN: | 0223-5234 |
| Popis: | Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected tropical diseases (NTDs) according to World Health Organization. It is estimated that 8-10 million people are infected worldwide, mainly in Latin America. Chagas disease is caused by the parasite Trypanosoma cruzi and is characterized by two phases: acute and chronic. The current therapy for Chagas disease is limited to drugs such as nifurtimox and benznidazole, which are effective in treating only the acute phase of the disease. In addition, several side effects ranging from hypersensitivity to bone marrow depression and peripheral polyneuropathy have been associated with these drugs. Therefore, the current challenge is to find new effective and safe drugs against this NTD. The aim of this review is to describe the advances in the medicinal chemistry of new anti-chagasic compounds reported in the literature in the last five years. We report promising prototypes for drug discovery identified through target-based and phenotype-based strategies and present some important targets for the development of new synthetic compounds. |
| Databáze: | OpenAIRE |
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