Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle
| Autor: | Anna Woloszynska, Peter J. Frederick, Abhilash Samykutty, Dennis Otali, Molly W. McNally, Benjamin L. Fouts, Jacek B. Jasinski, Jie Liu, William E. Grizzle, Alexandra Thomas, Phillip Chuong, Neveen Said, Lacey R. McNally, Akiko Chiba |
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| Rok vydání: | 2018 |
| Předmět: |
Near-Infrared Fluorescence Imaging
Materials science Paclitaxel Theranostic Nanomedicine Multispectral image Biophysics Mice Nude Nanoparticle Antineoplastic Agents Bioengineering Nanotechnology 02 engineering and technology Article Intersection (Euclidean geometry) Carboplatin Photoacoustic Techniques Biomaterials Mice 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Tumor Microenvironment medicine Animals Humans Tomography Ovarian Neoplasms Mesoporous silica Silicon Dioxide 021001 nanoscience & nanotechnology medicine.disease Mechanics of Materials 030220 oncology & carcinogenesis Ceramics and Composites Nanoparticles Female 0210 nano-technology Ovarian cancer Porosity |
| Zdroj: | Biomaterials. 182:114-126 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2018.08.001 |
| Popis: | At the intersection of the newly emerging fields of optoacoustic imaging and theranostic nanomedicine, promising clinical progress can be made in dismal prognosis of ovarian cancer. An acidic pH targeted wormhole mesoporous silica nanoparticle (V7-RUBY) was developed to serve as a novel tumor specific theranostic nanoparticle detectable using multispectral optoacoustic tomographic (MSOT) imaging. We report the synthesis of a small, < 40 nm, biocompatible asymmetric wormhole pore mesoporous silica core particle that has both large loading capacity and favorable release kinetics combined with tumor-specific targeting and gatekeeping. V7-RUBY exploits the acidic tumor microenvironment for tumor-specific targeting and tumor-specific release. In vitro, treatment with V7-RUBY containing either paclitaxel or carboplatin resulted in increased cell death at pH 6.6 in comparison to drug alone (p10X higher than in the kidney using both multispectral optoacoustic tomography (MSOT) imaging with secondary confirmation using near infrared fluorescence imaging (p |
| Databáze: | OpenAIRE |
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