Antioxidant and Chemopreventive Effect of Aliophen® Formulation Based on Malts and Hops
| Autor: | Angelo A. Izzo, Stefania Bilotto, Francesca Borrelli, Daniela Rigano, Gian Luigi Russo, Idolo Tedesco, Maria Russo, Fabrizio Tarricone, Carmela Spagnuolo |
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| Přispěvatelé: | Tedesco, I., Spagnuolo, C., Bilotto, S., Izzo, A. A., Borrelli, F., Rigano, D., Russo, M., Tarricone, F., Russo, G. L. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antioxidant antioxidant Physiology Colorectal cancer medicine.medical_treatment Clinical Biochemistry medicine.disease_cause Biochemistry Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine alcohol-free beer medicine chemoprevention Food science Molecular Biology polyphenols Azoxymethane lcsh:RM1-950 Cancer food and beverages Cell Biology medicine.disease Hemolysis lcsh:Therapeutics. Pharmacology 030104 developmental biology chemistry colon cancer Polyphenol 030220 oncology & carcinogenesis Carcinogenesis Lipoprotein |
| Zdroj: | Antioxidants Volume 10 Issue 1 Antioxidants, Vol 10, Iss 29, p 29 (2021) Antioxidants 10 (2021). doi:10.3390/antiox10010029 info:cnr-pdr/source/autori:Tedesco, Idolo; Spagnuolo, Carmela; Bilotto, Stefania; Izzo, Angelo A.; Borrelli, Francesca; Rigano, Daniela; Russo, Maria; Tarricone, Fabrizio; Russo, Gian Luigi/titolo:Antioxidant and Chemopreventive Effect of Aliophen(R) Formulation Based on Malts and Hops/doi:10.3390%2Fantiox10010029/rivista:Antioxidants/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:10 |
| ISSN: | 2076-3921 |
| DOI: | 10.3390/antiox10010029 |
| Popis: | Experimental and clinical studies evidenced the health effects of moderate consumption of beer, mainly due to the presence of bioactive compounds, such as polyphenols, vitamins, or fibers. To exploit the potential beneficial effect on health and in disease prevention of these compounds, a new beverage based on barley malts and hops named Aliophen® has been designed, through a patented production process, with a high total polyphenolic amount compared to alcohol-free beer and similar to the one present in light and dark beers. In the present study, the antioxidant activity of Aliophen® against low-density lipoprotein (LDL) oxidation and its ability to protect erythrocytes from hemolysis have been characterized. Moreover, the chemopreventive effect of Aliophen® against colon cancer has been assessed, employing a mouse model of chemically induced carcinogenesis using azoxymethane (AOM). Data obtained showed that Aliophen at a low dose (3 mg/kg) inhibited the formation of preneoplastic lesions, polyps, and tumors. At higher doses (300 mg/kg) the protective effect was measured in the first phase of the onset of cancer. The antioxidant properties of Aliophen® were also observed in AOM-treated mice where it increased the serum antioxidant capacity. Based on the data presented, Aliophen® can exert promising health effects, including an anticancer capacity presumably associated with its antioxidant properties. |
| Databáze: | OpenAIRE |
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