The safety and effectiveness of HBV vaccination in patients with juvenile idiopathic arthritis controlled by treatment
| Autor: | Tomoko Takezaki, Yasuhito Nerome, Tsuyoshi Yamato, Tomohiro Kubota, Harumi Akaike, Syuji Takei, Yoshifumi Kawano, Yuichi Yamasaki, Hiroyuki Imanaka, Yukiko Nonaka |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Hepatitis B virus medicine.medical_specialty Adolescent Arthritis medicine.disease_cause Biological Factors Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Juvenile Outpatient clinic Hepatitis B Vaccines In patient Prospective Studies 030212 general & internal medicine Seroconversion Child skin and connective tissue diseases Adverse effect 030203 arthritis & rheumatology business.industry Vaccination Hepatitis B Prognosis medicine.disease Arthritis Juvenile Child Preschool Immunology Female business Follow-Up Studies |
| Zdroj: | Modern Rheumatology. 26:368-371 |
| ISSN: | 1439-7609 1439-7595 |
| DOI: | 10.3109/14397595.2015.1085608 |
| Popis: | To evaluate the safety and effectiveness of hepatitis B virus (HBV) vaccination in patients with juvenile idiopathic arthritis (JIA) controlled by treatment.Among 49 patients with juvenile idiopathic arthritis (JIA) at the outpatient clinic of Kagoshima University Hospital, we enrolled 25 who were controlled by treatment. All children were unimmunized and were vaccinated against HBV according to the schedule. Their responses to the vaccine and vaccine adverse events were examined during their visits.Nineteen of the 25 patients with JIA controlled by treatment developed effective antibody responses (76%). All eight patients with JIA below 10 years of age achieved seroconversion. The seroconversion was not influenced by biologics. Five adverse events were observed (6.7%). The rate of all adverse events did not surpass that of a previous report, and all adverse events were immediately resolved. None of the patients with JIA experienced a flare-up or clinical deterioration related to the vaccination.HBV vaccination is safe and effective. Pediatric rheumatologists should consider HBV vaccination for unimmunized patients with JIA, because the response to HBV vaccine might be influenced by age, and children have a higher risk for potential HBV infection than adults. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|