Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3)
| Autor: | Beckmann, L., Hüsing, A., Setiawan, V. W., Amiano, P., Clavel-Chapelon, F., Chanock, S. J., Cox, D. G., Diver, R., Dossus, L., Feigelson, H. S., Haiman, C., Hallmans, G., Hayes, R. B., Henderson, B. E., Hoover, R. N., Hunter, D. J., Khaw, K., Kolonel, L. N., Kraft, P., Lund, E., Le Marchand, L., Peeters, P. H. M., Riboli, E., Stram, D., Thomas, G., Thun, M. J., Tumino, R., Trichopoulos, D., Vogel, U., Willett, W. C., Yeager, M., Ziegler, R., Hankinson, S. E., Kaaks, R., Renseigné, Non |
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| Přispěvatelé: | Public Health Division of Gipuzkoa, Basque Government, CIBER en Salud Pública, CIBERSP, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Gustave Roussy (IGR), Equipe 06, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Division of Epidemiology, Public Health and Primary Care, Imperial College London, Laboratoire des Procédés en Milieux Granulaires (LPMG-EMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Civile - M.P.Arezzo Hospital, Department Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Endocrinology
Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry MESH: Risk Assessment Biochemistry Body Mass Index Cohort Studies 0302 clinical medicine Endocrinology Sex hormone-binding globulin MESH: Hormones Ethnicity polycyclic compounds Hormone metabolism Prospective cohort study Gonadal Steroid Hormones MESH: Cohort Studies Testosterone MESH: Genetic Association Studies MESH: Gonadal Steroid Hormones MESH: Aged 0303 health sciences MESH: Middle Aged biology MESH: Polymorphism Single Nucleotide Age Factors MESH: Genetic Predisposition to Disease Middle Aged 3. Good health Europe Postmenopause MESH: Premenopause 030220 oncology & carcinogenesis Cohort Female Steroids MESH: Ethnic Groups hormones hormone substitutes and hormone antagonists MESH: Postmenopause Cohort study medicine.medical_specialty endocrine system Breast Neoplasms [SDV.CAN]Life Sciences [q-bio]/Cancer Polymorphism Single Nucleotide Risk Assessment MESH: Body Mass Index 03 medical and health sciences Internal medicine medicine Humans Genetic Predisposition to Disease Alleles Genetic Association Studies 030304 developmental biology Aged MESH: Age Factors MESH: Humans MESH: Alleles Biochemistry (medical) JCEM Online: Brief Reports Hormones MESH: Steroids Steroid hormone Premenopause biology.protein MESH: Europe MESH: Female Steroid hormone metabolism MESH: Breast Neoplasms |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2011, 96 (2), pp.E360-7. ⟨10.1210/jc.2010-0912⟩ |
| ISSN: | 0021-972X 1945-7197 |
| DOI: | 10.1210/jc.2010-0912⟩ |
| Popis: | International audience; CONTEXT: Sex steroids play a central role in breast cancer development. OBJECTIVE: This study aimed to relate polymorphic variants in 36 candidate genes in the sex steroid pathway to serum concentrations of sex steroid hormones and SHBG. DESIGN: Data on 700 genetic polymorphisms were combined with existing hormone assays and data on breast cancer incidence, within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nurses' Health Study (NHS) cohorts; significant findings were reanalyzed in the Multiethnic Cohort (MEC). SETTING AND PARTICIPANTS: We analyzed data from a pooled sample of 3852 pre- and postmenopausal Caucasian women from EPIC and NHS and 454 postmenopausal women from MEC. MAIN OUTCOME MEASURES: Outcome measures were SHBG, testosterone, dehydroepiandrosterone (DHEAS), androstenedione, estrone (E1), and estradiol (E2) as well as breast cancer risk. RESULTS: Globally significant associations were found among pre- and postmenopausal women combined between levels of SHBG and the SHBG gene and between DHEAS and the FSHR and AKR1C3 genes. Among postmenopausal women, serum E1 and E2 were significantly associated with the genes CYP19 and FSHR, and E1 was associated with ESR1. None of the variants related to serum hormone levels showed any significant association with breast cancer risk. CONCLUSIONS: We confirmed associations between serum levels of SHBG and the SHBG gene and of E1 and E2 and the CYP19 and ESR1 genes. Novel associations were observed between FSHR and DHEAS, E1, and E2 and between AKR1C3 and DHEAS. |
| Databáze: | OpenAIRE |
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