Survival among patients with composite and sequential lymphoma between primary mediastinal lymphoma/diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A population-based study
| Autor: | Haizhu Chen, Xiumei Dai, Dan Liu, Yunxia Tao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty China macromolecular substances Mediastinal Neoplasms Young Adult hemic and lymphatic diseases Internal medicine Composite lymphoma Epidemiology polycyclic compounds Classical Hodgkin lymphoma Medicine Humans Aged Retrospective Studies Aged 80 and over business.industry Significant difference food and beverages Neoplasms Second Primary Hematology Chemoradiotherapy Middle Aged medicine.disease Prognosis Hodgkin Disease Lymphoma Population based study Survival Rate Primary Mediastinal Lymphoma Female Lymphoma Large B-Cell Diffuse business Diffuse large B-cell lymphoma Follow-Up Studies |
| Zdroj: | Leukemia research. 111 |
| ISSN: | 1873-5835 |
| Popis: | Background Data on composite and sequential lymphoma between primary mediastinal lymphoma/diffuse large B-cell lymphoma (LBCL) and classical Hodgkin lymphoma (cHL) are rare. Methods We identified 25 cases with composite lymphoma (CL), 116 cases developing LBCL as a second primary cancer after cHL (cHL-LBCL), and 74 cases developing cHL as a second primary cancer after LBCL (LBCL-cHL) from the Surveillance, Epidemiology, and End Results (SEER) 18 database. Comparisons of overall survival (OS) and lymphoma cause-specific survival (CSS) between patients with cHL-LBCL or cHL-LBCL and their de novo counterparts were performed. Results The 5-year OS of patients with CL was 74.8 %. No significant difference in unadjusted OS and lymphoma CSS were observed between patients with de novo LBCL (LBCL-1 group) and patients with cHL-LBCL. However, the age- and stage-adjusted cHL-LBCL group had inferior OS and lymphoma CSS compared with that in the LBCL-1 group. The unadjusted and adjusted OS and lymphoma CSS in the LBCL-cHL group were significantly worse than patients with de novo cHL. Conclusions CL between LBCL and cHL may have good outcomes. cHL survivors had poorer outcomes after a LBCL diagnosis versus patients with LBCL-1. Significantly poor outcomes were observed in patients with LBCL-cHL compared with patients with de novo cHL. |
| Databáze: | OpenAIRE |
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