Novel insights into the assessment of risk of upper gastrointestinal bleeding in decompensated cirrhotic children
| Autor: | Dana Dumitriu, Caroline Pregardien, Francis Veyckemans, Stéphane Eeckhoudt, Cedric Hermans, Philippe Clapuyt, Thibault Helleputte, Raymond Reding, Thierry Detaille, Thierry Pirotte, Isabelle Scheers, Nicolas Bonnet, Renaud Menten, Jérôme Paul, Françoise Smets, Etienne Sokal, Xavier Stéphenne, Sharat Varma |
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| Přispěvatelé: | UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - (SLuc) Service d'anesthésiologie, UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service de biologie hématologique, UCL - (SLuc) Service d'hématologie, UCL - (SLuc) Centre de thérapie tissulaire et cellulaire, UCL - (SLuc) Centre de malformations vasculaires congénitales |
| Rok vydání: | 2018 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Platelet Aggregation Waiting Lists 030232 urology & nephrology 030230 surgery Esophageal varices Chronic liver disease Esophageal and Gastric Varices Gastroenterology End Stage Liver Disease 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Hypertension Portal medicine Coagulopathy Humans Prospective Studies Child Blood Coagulation Upper gastrointestinal bleeding Transplantation Hemostasis business.industry Fibrinogen Infant Endoscopy Gastric varices medicine.disease Liver Transplantation Child Preschool Pediatrics Perinatology and Child Health Female business Varices Gastrointestinal Hemorrhage Platelet dysfunction |
| Zdroj: | Pediatric Transplantation, Vol. 23, no. 4, p. e13390 [1-11] (2019) |
| ISSN: | 1399-3046 |
| Popis: | OBJECTIVES: Cirrhotic children wait-listed for liver transplant are prone to bleeding from gastrointestinal varices. Grade 2-3 esophageal varices, red signs, and gastric varices are well-known risk factors. However, the involvement of hemostatic factors remains controversial because of the rebalanced state of coagulation during cirrhosis. METHODS: Children suffering from decompensated cirrhosis were prospectively included while being on waitlist. Portal hypertension was assessed by ultrasound and endoscopy. Coagulopathy was evaluated through conventional tests, thromboelastometry, and platelet function testing. The included children were followed up until liver transplantation, and all bleeding episodes were recorded. Children with or without bleeding were compared according to clinical, radiological, endoscopic, and biological parameters. In addition, validation of a predictive model for risk of variceal bleeding comprising of grade 2-3 esophageal varices, red spots, and fibrinogen level |
| Databáze: | OpenAIRE |
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