Consistency and Stability of Motor Subtype Classifications in Patients With de novo Parkinson’s Disease
| Autor: | Lanting Li, Ping Hua, Jingru Ren, Pingyi Xu, Chenxi Pan, Li-Gang Xu, Wenbin Zhang, Li Zhang, Yuqian Li, Weiguo Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Longitudinal study medicine.medical_specialty Parkinson's disease Postural instability postural instability and gait difficulty Motor symptoms lcsh:RC321-571 03 medical and health sciences de novo Parkinson’s disease 0302 clinical medicine Cohen's kappa Consistency (statistics) Internal medicine medicine In patient akinetic-rigid lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry business.industry tremor-dominant General Neuroscience medicine.disease non-motor symptoms 030104 developmental biology Gait difficulty business motor subtypes 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Neuroscience, Vol 15 (2021) |
| DOI: | 10.3389/fnins.2021.637896/full |
| Popis: | ObjectivePatients with Parkinson’s disease (PD) are commonly classified into subtypes based on motor symptoms. The aims of the present study were to determine the consistency between PD motor subtypes, to assess the stability of PD motor subtypes over time, and to explore the variables influencing PD motor subtype stability.MethodsThis study was part of a longitudinal study of de novo PD patients at a single center. Based on three different motor subtype classification systems proposed by Jankovic, Schiess, and Kang, patients were respectively categorized as tremor-dominant/indeterminate/postural instability and gait difficulty (TD/indeterminate/PIGD), TDS/mixedS/akinetic-rigidS (ARS), or TDK/mixedK/ARK at baseline evaluation and then re-assessed 1 month later. Demographic and clinical characteristics were recorded at each evaluation. The consistency between subtypes at baseline evaluation was assessed using Cohen’s kappa coefficient (κ). Additional variables were compared between PD subtype groups using the two-sample t-test, Mann–Whitney U-test or Chi-squared test.ResultsOf 283 newly diagnosed, untreated PD patients, 79 were followed up at 1 month. There was fair agreement between the Jankovic, Schiess, and Kang classification systems (κS = 0.383 ± 0.044, κK = 0.360 ± 0.042, κSK = 0.368 ± 0.038). Among the three classification systems, the Schiess classification was the most stable and the Jankovic classification was the most unstable. The non-motor symptoms questionnaire (NMSQuest) scores differed significantly between PD patients with stable and unstable subtypes based on the Jankovic classification (p = 0.008), and patients with a consistent subtype had more severe NMSQuest scores than patients with an inconsistent subtype.ConclusionFair consistency was observed between the Jankovic, Schiess, and Kang classification systems. For the first time, non-motor symptoms (NMSs) scores were found to influence the stability of the TD/indeterminate/PIGD classification. Our findings support combining NMSs with motor symptoms to increase the effectiveness of PD subtypes. |
| Databáze: | OpenAIRE |
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