Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts
| Autor: | Gencer, B., Collet, T.H., Virgini, V., Bauer, D.C., Gussekloo, J., Cappola, A.R., Nanchen, D., Elzen, W.P.J. den, Balmer, P., Luben, R.N., Iacoviello, M., Triggiani, V., Cornuz, J., Newman, A.B., Khaw, K.T., Jukema, J.W., Westendorp, R.G.J., Vittinghoff, E., Aujesky, D., Rodondi, N., Thyroid Studies Collaboration |
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| Přispěvatelé: | Thyroid Studies Collaboration |
| Rok vydání: | 2012 |
| Předmět: |
Male
endocrine system diseases Thyrotropin heart failure Comorbidity 030204 cardiovascular system & hematology Cardiorespiratory Medicine and Haematology Cardiovascular thyroid 0302 clinical medicine cohort studies Risk Factors 80 and over Prospective Studies Prospective cohort study Subclinical infection Aged 80 and over medicine.diagnostic_test Thyroid Middle Aged medicine.anatomical_structure Heart Disease Public Health and Health Services Female epidemiology Cardiology and Cardiovascular Medicine hormones hormone substitutes and hormone antagonists Cohort study Risk Adult endocrine system medicine.medical_specialty Management of heart failure Clinical Sciences 030209 endocrinology & metabolism Aged Follow-Up Studies Heart Failure/epidemiology Humans Hypothyroidism/blood Hypothyroidism/epidemiology Sensitivity and Specificity Thyrotropin/blood Thyroxine/blood Thyroid function tests Article 03 medical and health sciences Hypothyroidism Clinical Research Physiology (medical) Internal medicine medicine Metabolic and endocrine business.industry Thyroid Studies Collaboration medicine.disease meta-analysis Thyroxine Endocrinology Cardiovascular System & Hematology Heart failure business |
| Zdroj: | Circulation, vol 126, iss 9 Circulation Circulation, 126(9), 1040-U100 Circulation, vol. 126, no. 9, pp. 1040-1049 |
| Popis: | Background— American College of Cardiology/American Heart Association guidelines for the diagnosis and management of heart failure recommend investigating exacerbating conditions such as thyroid dysfunction, but without specifying the impact of different thyroid-stimulation hormone (TSH) levels. Limited prospective data exist on the association between subclinical thyroid dysfunction and heart failure events. Methods and Results— We performed a pooled analysis of individual participant data using all available prospective cohorts with thyroid function tests and subsequent follow-up of heart failure events. Individual data on 25 390 participants with 216 248 person-years of follow-up were supplied from 6 prospective cohorts in the United States and Europe. Euthyroidism was defined as TSH of 0.45 to 4.49 mIU/L, subclinical hypothyroidism as TSH of 4.5 to 19.9 mIU/L, and subclinical hyperthyroidism as TSH P for quadratic pattern P for trend P for trend=0.047). Risks remained similar after adjustment for cardiovascular risk factors. Conclusion— Risks of heart failure events were increased with both higher and lower TSH levels, particularly for TSH ≥10 and |
| Databáze: | OpenAIRE |
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