Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection
| Autor: | Luigi Lembo-Fazio, Marialuisa Barbagallo, Antonio Molinaro, Anna-Karin Bruno, Sara Berardi, Giacomo Rossi, Cecilia Garlanda, Sébastien Jaillon, Ida Paciello, Maria Lina Bernardini, Valeria Ciancarella, Shiri Meron-Sudai, Dani Cohen |
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| Přispěvatelé: | Ciancarella, Valeria, Lembo-Fazio, Luigi, Paciello, Ida, Bruno, Anna-Karin, Jaillon, Sébastien, Berardi, Sara, Barbagallo, Marialuisa, Meron-Sudai, Shiri, Cohen, Dani, Molinaro, Antonio, Rossi, Giacomo, Garlanda, Cecilia, Bernardini, Maria Lina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Shigellosis QH301-705.5 Immunology medicine.disease_cause Microbiology Shigella flexneri Lipid A 03 medical and health sciences Mice Genetic Immunity Virology medicine Genetics Animals Humans Shigella Biology (General) Molecular Biology pentraxin-3 pathogen Dysentery Bacillary Innate immune system biology Animal Bacillary dysentery Pathogenic bacteria RC581-607 medicine.disease biology.organism_classification Immunity Innate Mice Inbred C57BL Serum Amyloid P-Component 030104 developmental biology C-Reactive Protein Parasitology Immunologic diseases. Allergy Human |
| Zdroj: | PLOS Pathogens PLoS Pathogens, Vol 14, Iss 12, p e1007469 (2018) |
| ISSN: | 1553-7374 |
| DOI: | 10.1371/journal.ppat.1007469 |
| Popis: | Shigella spp. are pathogenic bacteria that cause bacillary dysentery in humans by invading the colonic and rectal mucosa where they induce dramatic inflammation. Here, we have analyzed the role of the soluble PRR Pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity. Mice that had been intranasally infected with S. flexneri were rescued from death by treatment with recombinant PTX3. In vitro PTX3 exerts the antibacterial activity against Shigella, impairing epithelial cell invasion and contributing to the bactericidal activity of serum. PTX3 is produced upon LPS-TLR4 stimulation in accordance with the lipid A structure of Shigella. In the plasma of infected patients, the level of PTX3 amount only correlates strongly with symptom severity. These results signal PTX3 as a novel player in Shigella pathogenesis and its potential role in fighting shigellosis. Finally, we suggest that the plasma level of PTX3 in shigellosis patients could act as a biomarker for infection severity. |
| Databáze: | OpenAIRE |
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