The Prognosis and Recurrence Pattern of Right- and Left-Sided Colon Cancer in Stage II, Stage III, and Liver Metastasis After Curative Resection
| Autor: | Naoki Kamitani, Fumikazu Koyama, Takahiro Yoshikawa, Hiroyuki Kuge, Takayuki Nakamoto, Daisuke Hokuto, Takeshi Takei, Yasuko Matsuo, Shinsaku Obara, Yasuyuki Nakamura, Takeo Nomi, Yayoi Matsumoto, Tomomi Sadamitsu, Kohei Fukuoka, Masayuki Sho, Yosuke Iwasa |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Colorectal cancer left-sided colon cancer RC799-869 Disease Gastroenterology Metastasis 03 medical and health sciences Cecum 0302 clinical medicine Internal medicine medicine Stage (cooking) right-sided colon cancer Splenic flexure business.industry Cancer Diseases of the digestive system. Gastroenterology medicine.disease Primary tumor 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Original Article Surgery business colorectal liver metastasis |
| Zdroj: | Annals of Coloproctology, Vol 37, Iss 5, Pp 326-336 (2021) Annals of Coloproctology |
| ISSN: | 2287-9722 2287-9714 |
| DOI: | 10.3393/ac.2020.09.14 |
| Popis: | Purpose Primary tumor location of colon cancer has been reported to affect the prognosis after curative resection. However, some reports suggested the impact was varied by tumor stage. This study analyzed the prognostic impact of the sidedness of colon cancer in Stages II, III, and liver metastasis after curative resection using propensity matched analysis. Methods Right-sided colon cancer was defined as a tumor located from cecum to splenic flexure, while any more distal colon cancer was defined as a left-sided colon cancer. Patients who underwent curative resection at Nara Medical University hospital between 2000 and 2016 were analyzed. Results There were 110 patients with Stage II, 100 patients with Stage III, and 106 patients with liver metastasis. After propensity matching, 28 pairs with Stage II and 32 pairs with Stage III were identified. In the patients with Stage II, overall survival and recurrence-free survival were not significantly different for right- and left-sided colon cancers. In the patients with Stage III, overall survival and recurrence-free survival were significantly worse in right-sided colon cancer. In those with liver metastasis, overall survival of right-sided colon cancer was significantly worse than left-sided disease, while recurrence-free survival was similar. Regarding metachronous liver metastasis, the difference was observed only in the patients whose primary colon cancer was stage III. In each stage, significantly higher rate of peritoneal recurrence was found in those with right-sided colon cancer. Conclusion Sidedness of colon cancer had a significant and varied prognostic impact in patients with Stage II, III, and liver metastasis after curative resection. |
| Databáze: | OpenAIRE |
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