LC-MS/MS methods for albendazole analysis in feed and its metabolite residues in fish fillet and a leaching study in feed after an alternative procedure for drug incorporation
| Autor: | Osvaldo de Freitas, Agnaldo Fernando Baldo da Silva, Zenaís Busatto, Jonas Augusto Rizzato Paschoal |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Analyte Meat Calibration curve Health Toxicology and Mutagenesis Metabolite Liquid-Liquid Extraction Guidelines as Topic Toxicology Quechers Albendazole 01 natural sciences Commercial fish feed 03 medical and health sciences chemistry.chemical_compound Coated Materials Biocompatible Limit of Detection Tandem Mass Spectrometry medicine Animals Humans Leaching (agriculture) Cellulose Biotransformation Anthelmintics Chromatography 010401 analytical chemistry Public Health Environmental and Occupational Health Fish fillet General Chemistry General Medicine Animal Feed Drug Residues 0104 chemical sciences Drug Liberation Kinetics 030104 developmental biology chemistry Environmental chemistry Characiformes Brazil CONTAMINAÇÃO DE ALIMENTOS Food Science medicine.drug Chromatography Liquid |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | This paper describes the development of analytical methods for the quantification of albendazole (ABZ) in fish feed and ABZ and its main known metabolites (albendazole sulfoxide, albendazole sulfone and albendazole aminosulfone) in fish fillet employing LC-MS/MS. In order to assess the reliability of the analytical methods, evaluation was undertaken as recommended by related guides proposed by the Brazilian Ministry of Agriculture for analytical method validation. The calibration curve for ABZ quantification in feed showed adequate linearity (r > 0.99), precision (CV 0.99) for all analytes, precision (CV |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|