The presence of p53 protein in relation to Ki-67 as cellular proliferation marker in head and neck squamous cell carcinoma and adjacent dysplastic mucosa
| Autor: | G.J. Hordijk, P.J. Slootweg, R. Koole |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Biology medicine.disease_cause Immunoenzyme Techniques Basal (phylogenetics) medicine Atypia Humans Proliferation Marker Aged Mucous Membrane Nuclear Proteins Middle Aged medicine.disease Head and neck squamous-cell carcinoma Epithelium Neoplasm Proteins Ki-67 Antigen medicine.anatomical_structure Oncology Head and Neck Neoplasms Dysplasia Ki-67 Carcinoma Squamous Cell biology.protein Female Tumor Suppressor Protein p53 Carcinogenesis Precancerous Conditions Cell Division |
| Zdroj: | European Journal of Cancer Part B: Oral Oncology. 30:138-141 |
| ISSN: | 0964-1955 |
| Popis: | Paraffin embedded material from 15 patients suffering from head and neck squamous cell carcinoma (NNSCC) bordered by dysplastic mucosal areas was immunohistochemically investigated for the presence of p53 protein and Ki-67 proliferation marker. p53 protein was present in 9 cases (60%), invariably in invasive cancer areas as well as in adjacent non-invasive dysplastic mucosa. Only cells exhibiting atypia contained p53 protein. Ki-67 proliferation marker was present in the basal cells of the normal epithelium and more extensive in dysplasias and HNSCC. The presence of Ki-67 closely coincided with p53 protein in the 9 cases exhibiting this. No differences in Ki-67 expression were found between p53 positive and negative cases. It is concluded that the appearance of p53 protein occurs early in carcinogenesis but that cells also may show increased proliferation without involving immunohistochemically detectable alterations in the p53 gene. |
| Databáze: | OpenAIRE |
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