Model for Aging in the Basal Forebrain Cholinergic System
| Autor: | G Wortwein, Juan Yu, Zezong Gu, J R Perez-Polo |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Central Nervous System
Aging Physiology Clinical Biochemistry Central nervous system Cholinergic Agents Hippocampus Biology Biochemistry Prosencephalon Immunotoxin medicine Animals Humans Receptors Cholinergic Cholinergic neuron N-Glycosyl Hydrolases Molecular Biology Loss function General Environmental Science Neurons Basal forebrain Immunotoxins NF-kappa B Antibodies Monoclonal Brain Cell Biology Anatomy Saporins Rats Nerve growth factor medicine.anatomical_structure nervous system Ribosome Inactivating Proteins Type 1 General Earth and Planetary Sciences Cholinergic Neuroscience |
| Zdroj: | Antioxidants & Redox Signaling. 2:437-447 |
| ISSN: | 1557-7716 1523-0864 |
| DOI: | 10.1089/15230860050192215 |
| Popis: | A key component of the cognitive deficits associated with aging is the loss of function of cholinergic neurons in the basal forebrain due to neuronal losses and decreased cholinergic function of spared neurons. A model to mimic one aspect of this phenomenon is to kill cholinergic neurons selectively in the basal forebrain via administration of the immunotoxin IgG-192-saporin. Here we discuss apoptotic regulators, such as nerve growth factor, in age-associated changes present in the cholinergic system and the role of the NF-kappaB signaling system in cellular commitment to apoptosis. We also examine the age-associated decline in intrinsic response mechanisms, which may account for the age-associated reduction in recovery from both acute and chronic insults to the central nervous system. |
| Databáze: | OpenAIRE |
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